Neonatal Med.  2019 Feb;26(1):48-54. 10.5385/nm.2019.26.1.48.

Comparison of Clinical Factors and Neurodevelopmental Outcomes between Early- and Late-Onset Periventricular Leukomalacia in Very Low Birth Weight Infants

• Bae M
• Lee N
• Han YM
• Park KH
• Byun SY

• KMID: 2440700
• DOI: http://doi.org/10.5385/nm.2019.26.1.48

Abstract

PURPOSE
To analyze and compare the clinical factors and neurodevelopmental outcomes compare early- and late-onset periventricular leukomalacia (PVL) in very low birth weight infants (VLBWI).
METHODS
We performed a retrospective study involving 199 newborn infants weighing < 1,500 g admitted to the neonatal intensive care unit between March 2009 and December 2015. VLBWI with PVL were categorized into early- and late-onset PVL groups based on the time of diagnosis based on 28 days of age. We analyzed the clinical factors and neurodevelopmental outcomes between the groups.
RESULTS
The incidence rate of PVL was 10.1% (16/158). The Apgar score at 1 minute and the mean duration of tocolytic therapy were associated with the development of PVL. The incidence rate of premature rupture of membranes (PROM) was significantly higher in the early-onset PVL group (P=0.041). No significant differences were observed in neurodevelopmental outcomes between the early- and late-onset PVL groups.
CONCLUSION
Results suggest that a higher incidence of PROM was associated with clinical characteristics in the early-onset PVL group. No significant intergroup differences were observed in neurodevelopmental outcomes; however, the Bayley Scales of Infant Development-III scores were lower in the early-onset PVL group.

Keyword

Leukomalacia, periventricular; Fetal membranes, premature rupture; Infant, very low birth weight

MeSH Terms

Apgar Score
Diagnosis
Female
Fetal Membranes, Premature Rupture
Humans
Incidence
Infant*
Infant, Newborn
Infant, Very Low Birth Weight*
Intensive Care, Neonatal
Leukomalacia, Periventricular*
Membranes
Pregnancy
Retrospective Studies
Rupture
Tocolysis
Weights and Measures

Figure

• 

  Figure 1. Flowchart showing details of infants included in the study. Abbreviation: PVL, periventricular leukomalacia.

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