Korean J Pediatr Infect Dis.  2000 May;7(1):120-128. 10.14776/kjpid.2000.7.1.120.

Immunogenicity and Reactogenicity of Inactivated HM175 Strain Hepatitis A Vaccine in Healthy Korean Children

• Kim CH
• Pyun BY
• Hong YJ
• Kang JH

• KMID: 2440232
• DOI: http://doi.org/10.14776/kjpid.2000.7.1.120

Abstract

PURPOSE
Active immunization against hepatitis A with an inactivated vaccine reveals excellent immunogenicity, tolerability and protective efficacy. Inactivated hepatitis A vaccines have been selectively used since 1996 in Korea to prevent hepatitis A. This study was performed to assess the immunogenicity and reactogenicity after two doses of HM175 strain hepatitis A vaccine in healthy Korean children.
METHODS
128 healthy children(M/F; 65/63) aged 1 to 15 years, who were seronegative for hepaitatis A, participated in this study. A alum-adsorbed vaccine containing 720 EL.U of antigen form HM175 hepatitis A strain per 0.5 mL dose was injected intramuscularly on the deltoid area. The second dose was given 6 months later. Anti-HAV antibodies were measured by ELISA before and 1 month after each vaccination to assess the immunogenicity. Any local and general adverse events were reported by patients parents with the prepared questionnaire after each vaccination.
RESULTS
120 volunteers(M/F; 60/60) completed the whole series of the study. Seroconversion occurred in all cases after primary and booster vaccination. The mean anti-HAV antibody titer after primary vaccination was 389.2mIU/mL, and 3,609mIU/mL after booster vaccination. And levels of anti-HAV antibodies after booster immunization were significantly higher in female children. The most common local adverse event was soreness on the injection site, but it was mild and resolves within 3 days. Fever was not reported after booster vaccination.
CONCLUSION
Based on these data, we conclude that the inactivated HM175 strain hepatitis A vaccine is highly immunogenic and tolerable in healthy Korean children.

Keyword

Inactivated hepatitis A vaccine; Immunogenicity; Reactogenicity

MeSH Terms

Antibodies
Child*
Enzyme-Linked Immunosorbent Assay
Female
Fever
Hepatitis A Antibodies
Hepatitis A Vaccines*
Hepatitis A*
Hepatitis*
Humans
Immunization, Secondary
Korea
Parents
Seroconversion
Vaccination
Antibodies
Hepatitis A Antibodies
Hepatitis A Vaccines