Exp Mol Med.
2018 Mar;50(3):e453. 10.1038/emm.2017.290.
Whither systems medicine?
- Affiliations
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- 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
- 2Institute of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
- 3Fachbereich Informatik und Informationswissenschaft, Universität Konstanz, Konstanz, Germany.
- 4Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany.
- 5Integrative Research Institute for the Life Sciences, Institute for Theoretical Biology, Humboldt Universität, Berlin, Germany.
- 6Biologische Heilmittel Heel GmbH, Baden-Baden, Germany.
- 7Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
- 8Perinatal Epidemiology Unit, Hannover Medical School, Hannover, Germany.
- 9Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.
- 10Institute for Pathology, Neuropathology, Hannover Medical School, Hannover, Germany.
- 11Institute for Neuropathology, University Clinic of Freiburg, Freiburg, Germany.
- 12Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
- 13Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
- 14Center for Mathematics, Technische Universität München, Garching, Germany.
- 15Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
- 16Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 17BioQuant Center, University of Heidelberg, Heidelberg, Germany.
- 18Maastricht Center for Systems Biology, University of Maastricht, Maastricht, The Netherlands.
- 19Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany.
- 20Division of Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 21Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.
- 22Molecular Bioinformatics, Institute of Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.
- 23Center for Bioinformatics, University of Tübingen, Tübingen, Germany.
- 24Quantitative Biology Center, University of Tübingen, Tübingen, Germany.
- 25Biomolecular Interactions, Max Planck Institute for Developmental Biology, Tübingen, Germany.
- 26Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany.
- 27Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
- 28Biomax Informatics AG, Planegg (Munich), Germany.
- 29Department of Computational Biology and Applied Algorithmics, Max-Planck-Institut für Informatik, Saarbrücken, Germany.
- 30Institute for Systems Theory and Automatic Control, University of Stuttgart, Stuttgart, Germany.
- 31Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany.
- 32Department of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
- 33Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
- 34Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
- 35Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH-Aachen University Hospital, Aachen, Germany.
- 36Department of Medical Informatics, University Medical Center, Göttingen, Germany.
- 37Institute for Lung Research/iLung, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Germany, Member of the German Center for Lung Research, Marburg, Germany.
- 38Joint Research Center for Computational Biomedicine, AICES, RWTH Aachen University, Aachen, Germany.
- 39Department of Mathematics, Technische Universität München, Munich, Germany.
- 40Laboratory of Systems Tumor Immunology, Friedrich-Alexander University Erlangen-Nürnberg and Erlangen University Hospital, Erlangen, Germany.
- 41Department of Systems Biology and Bioinformatics, Rostock University, Rostock, Germany. olaf.wolkenhauer@uni-rostock.de
- 42Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa.
- KMID: 2440048
- DOI: http://doi.org/10.1038/emm.2017.290
Abstract
- New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.
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