Korean J Helicobacter Up Gastrointest Res.  2018 Sep;18(3):209-212. 10.7704/kjhugr.2018.18.3.209.

A Case of Amyloidosis Presenting as Lymphadenopathy at the Porta Hepatis

• Lee JI
• Kim JS
• Kim BW

• KMID: 2439832
• DOI: http://doi.org/10.7704/kjhugr.2018.18.3.209

Abstract

We report a rare case of systemic amyloidosis with gastrointestinal and lymph node involvement. A 64-year-old woman was admitted to our hospital with dyspepsia and weight loss. Initial esophagogastroduodenoscopy (EGD) revealed nonspecific findings, and abdominal computed tomography showed necrotizing lymphadenopathy at the porta hepatis. Laparoscopic lymph node biopsy was performed under suspicion of tuberculous lymphadenopathy, but a definite diagnosis was not established. Follow-up EGD performed 6 months later revealed multiple telangiectasia-like lesions at the gastric body, and endoscopic biopsy revealed amyloid deposition. Through additional blood and urine protein electrophoresis, the patient was finally diagnosed with systemic amyloidosis associated with multiple myeloma. She was treated with dexamethasone, thalidomide, and bortezomib; however, she died 3 months after diagnosis because of pneumonia and multiple organ failure.

Keyword

Amyloidosis; Lymphadenopathy; Multiple myeloma

MeSH Terms

Amyloidosis*
Biopsy
Bortezomib
Dexamethasone
Diagnosis
Dyspepsia
Electrophoresis
Endoscopy, Digestive System
Female
Follow-Up Studies
Humans
Lymph Nodes
Lymphatic Diseases*
Middle Aged
Multiple Myeloma
Multiple Organ Failure
Plaque, Amyloid
Pneumonia
Thalidomide
Weight Loss
Bortezomib
Dexamethasone
Thalidomide