J Korean Med Sci.  2017 Aug;32(8):1304-1311. 10.3346/jkms.2017.32.8.1304.

The Different Clinical Aspects of Pediatric Primary Airway Tumors in the Larynx, Trachea, and Bronchi

• Cho HJ
• Yoon J
• Lee E
• Lee YS
• Kim SY
• Roh J
• Kim DK
• Choi SH
• Park SI
• Kim YH
• Koh KN
• Im HJ
• Seo JJ
• Hong SJ
• Yu J

• KMID: 2439465
• DOI: http://doi.org/10.3346/jkms.2017.32.8.1304

Abstract

Primary airway tumors are rare in children and no literature reviewed their characteristics each location. We evaluate the clinical characteristics and outcomes of Korean children with primary airway tumors, from the larynx to bronchi. A retrospective chart review of children with primary tumors of the larynx, trachea, and bronchi at Asan Medical Center from January 2000 to July 2016 was conducted. Nineteen children were diagnosed with primary airway tumors of the larynx (47.4%), trachea (10.5%), and bronchi (42.1%). Median follow-up duration was 2.8 years and there were recurrences in 21.1%. Laryngeal tumors were associated with a younger median age at onset (2 months) and diagnosis (4 months), and most were relatively small (median size = 5.3 mm) and symptomatic. Tracheal and bronchial tumors were found in older children (age at onset and diagnosis > 11 years) and large (> 15.0 mm). Most (75%) patients with bronchial tumors were asymptomatic and all the patients with tracheal tumors were symptomatic. This study suggests that we should consider different the locations in primary airway tumor based on the age at onset and diagnosis, initial symptoms or signs, and size of tumor.

Keyword

Neoplasms; Larynx; Trachea; Bronchi; Pediatrics

MeSH Terms

Age of Onset
Bronchi*
Child
Chungcheongnam-do
Diagnosis
Follow-Up Studies
Humans
Larynx*
Pediatrics
Recurrence
Retrospective Studies
Trachea*

Figure

• 

  Fig. 1 Laryngoscopic findings demonstrating the tumor in the larynx (refer to Table 2). (A) RRP in both FVC and ventricle (thin circle), patient No. 7. (B) Subglottic hemangioma (thin circle), patient No. 4, (C) Ewing sarcoma (thin circle), patient No. 9.RRP = recurrent respiratory papillomatosis, FVC = false vocal cord.

• 

  Fig. 2 Work-up findings showing the pleomorphic adenoma in the trachea, patient No. 1 (refer to Table 3). (A) Extensive subcutaneous emphysema with pneumomediastinum on chest X-ray. (B) Homogenous mass on chest CT (thin arrow). (C) Severe airway obstruction on bronchoscopic view (thin arrow).CT = computed tomography.

• 

  Fig. 3 Carcinoid tumor in RMB indicated thin arrow, patient No. 7 (refer to Table 4). (A) Well-enhanced mass, initial chest X-ray and CT. (B) First metastasis on LUL and LLL, chest CT. (C) Second metastasis to L3 and T11, sagittal T2-weighted MRI.RMB = right main bronchus, CT = computed tomography, LUL = left upper lobe, LLL = left lower lobe, MRI = magnetic resonance imaging.

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