Korean J Urol Oncol.
2018 Aug;16(2):69-74. 10.22465/kjuo.2018.16.2.69.
Safety and Efficacy of the Coadministration of Sildenafil and Finasteride
- Affiliations
-
- 1Department of Urology, Hanyang University College of Medicine, Seoul, Korea. dr.jhchung@gmail.com
- 2Department of Urology, Yonsei University College of Medicine, Seoul, Korea.
- 3Zeus Man-Clinic, Busan, Korea.
- KMID: 2438597
- DOI: http://doi.org/10.22465/kjuo.2018.16.2.69
Abstract
- PURPOSE
The 5-alpha reductase inhibitors (5ARI) are one of the most commonly used medications for the treatment of benign prostatic hyperplasia (BPH). Phosphodiesterase type-5 inhibitors are also used to treat BPH. 5ARI is a drug with adverse effects of sexual dysfunction. In this study, we investigated the safety and efficacy of coadministration of finasteride and sildenafil on sexual function and lower urinary symptoms in patients with BPH.
MATERIALS AND METHODS
We retrospectively reviewed the medical records of patients who were receiving finasteride and sildenafil daily regimens for treatment of BPH in 2 university hospitals. Patients with adverse effects, vital sign, physical exam, laboratory test, 5-item version of the international index of erectile function (IIEF-5), International Prostate Symptom Score (IPSS), quality of life (QoL) were analyzed.
RESULTS
The number of patients analyzed in this study was 218. The mean age of the patients was 62.63±8.37 years and the mean duration of medication was 18.23±10.97 weeks. Significant changes were not observed in the vital signs measured before and after the drug administration. Compared with before treatment, improvement of lower urinary tract symptom (IPSS: 17.56±4.21 vs. 11.64±5.33, p < 0.001) was observed and improvement of sexual function (IIEF-5: 9.44±5.21 vs. 12.73±6.81, p < 0.001) was also confirmed.
CONCLUSIONS
Daily coadministration of finasteride and sildenafil for the treatment of BPH could be used safely, and improvement of lower urinary tract symptom as well as improvement of sexual function could be expected.
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