Int J Oral Biol.  2018 Sep;43(3):123-127. 10.11620/IJOB.2018.43.3.123.

Antimicrobial Effect of Polyphenon 60 against Streptococcus mutans and Streptococcus sobrinus

• Park TY
• Lim YK
• Kook JK

• KMID: 2437348
• DOI: http://doi.org/10.11620/IJOB.2018.43.3.123

Abstract

Polyphenon 60 refers to the mixture of catechins present in green tea. The aim of this study was to investigate the antimicrobial activities of polyphenon 60 against 4 strains of Streptococcus mutans and 2 strains of Streptococcus sorbrinus, which are the major causative bacteria of dental caries. The minimum bactericidal concentration (MBC) values of polyphenon 60 for S. mutans and S. sobrinus were determined and the effect of biofilm formation inhibition of that was evaluated. The MBC value of polyphenon 60 against the bacterial strains was 2.5 mg/ml except for one particular strain, S. mutans KCOM 1128 for which the value was 1.25 mg/ml. The results of biofilm formation inhibition assay revealed that polyphenon 60 inhibited biofilm formation more than 90% at a concentration of 2.5 mg/ml. It was apparent that polyphenon exhibited biofilm formation inhibition activity along with bactericidal effect against S. mutans and S. sobrinus. Therefore, it is proposed that polyphenon 60 as one of the components of bactericidal agents could be useful in developing oral hygiene products, toothpaste or gargling solution.

Keyword

polyphenon 60; cariogenic bacteria; bactericidal effect

MeSH Terms

Bacteria
Biofilms
Catechin
Dental Caries
Oral Hygiene
Streptococcus mutans*
Streptococcus sobrinus*
Streptococcus*
Tea
Toothpastes
Catechin
Tea
Toothpastes