Korean J Dermatol.  2018 Sep;56(8):489-493.

Circumscribed Palmar Hypokeratosis Showing Bowenoid Change Secondary to Human Papilloma Virus

• Jeong WS
• Jin WJ
• Moon SH
• Hwangbo H
• Lee SK

Abstract

Circumscribed palmar or plantar hypokeratosis is a rare condition characterized by the occurrence of an erythematous, well-circumscribed, and depressed macule or patch on the palms or soles. Histopathologically, it is characterized by sharp, stair-like abrupt thinning of the horny layer between the affected and unaffected skin. The pathogenesis of this condition remains unclear. Recently, the human papilloma virus has been implicated as a possible etiological contributor. Circumscribed palmar or plantar hypokeratosis usually shows a benign course. Previous reports have not described malignant changes in these lesions. However, its association with actinic keratosis has been reported in a previous case. We report a case of circumscribed palmar hypokeratosis showing bowenoid epidermal change with expression of the human papilloma virus types 6 and 16 in a patient who was successfully treated with ingenol mebutate gel and cryotherapy.

Keyword

Bowenoid epidermal change; Circumscribed palmar hypokeratosis; Cryotherapy; Human papilloma virus; Ingenol mebutate

MeSH Terms

Cryotherapy
Humans*
Keratosis, Actinic
Papillomaviridae*
Skin