Neonatal Med.  2018 Nov;25(4):144-152. 10.5385/nm.2018.25.4.144.

Clinical Features of Respiratory Syncytial Virus Infection in Neonates: A Single Center Study

Affiliations
  • 1Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Goyang, Korea. swyoon@nhimc.or.kr

Abstract

PURPOSE
The aim of this study was to investigate the clinical characteristics of Respiratory syncytial virus (RSV) infection during the neonatal period to provide information that is useful in clinical practice and suggest extension of the palivizumab administration.
METHODS
Neonates admitted to the National Health Insurance Service Ilsan Hospital neonatal intensive care unit due to respiratory symptoms and for whom multiplex reverse transcription-polymerase chain reaction and multiplex real time-polymerase chain reaction tests were performed between October 2011 and May 2016 were included in this study. Medical records were retrospectively reviewed, and data was collected for 156 neonates.
RESULTS
Among the 156 neonates, RSV was detected in 114 (73.1%), non-RSV in 25 (16%), and no virus in 17 (10.9%). The majority were full term infants (92.4%) and peak incidence of RSV infection was in January. Post-natal care center infection was more common in the RSV group (46.6%) than that in the other virus groups (24%, P=0.0243). Clinical symptoms were severe in the RSV group in contrast to that in the non-RSV or others groups. The RSV group frequently needed oxygen therapy (P=0.0001) and the duration of hospital stays were longer (P=0.0001).
CONCLUSION
RSV is a significant cause of respiratory infection in neonates and the severity is higher in contrast to that with other viral causes of infection. Infants in post-natal care centers have a high-risk of developing RSV infections; therefore, palivizumab administration may be considered in this group to prevent hospitalization and reduce the duration of hospital stay.

Keyword

Respiratory syncytial viruses; Newborn; Palivizumab; Post-natal care center

MeSH Terms

Hospitalization
Humans
Incidence
Infant
Infant, Newborn*
Intensive Care, Neonatal
Length of Stay
Medical Records
National Health Programs
Oxygen
Palivizumab
Respiratory Syncytial Viruses*
Retrospective Studies
Oxygen
Palivizumab

Figure

  • Figure 1. Seasonal and monthly distribution of respiratory syncytial virus (RSV) A, RSV B, and non-RSV viruses for a 5-year period from 2011 to 2016. Season 1: September 2011 to August 2012; Season 2: September 2012 to August 2013; Season 3: September 2013 to August 2014; Season 4: September 2014 to August 2015; and Season 5: September 2015 to May 2016.


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