J Genet Med.  2018 Jun;15(1):43-47. 10.5734/JGM.2018.15.1.43.

Partial molar pregnancy and coexisting fetus with Turner syndrome: Case report and literature review

• Park JE
• Park JK
• Cho IA
• Baek JC

• KMID: 2435973
• DOI: http://doi.org/10.5734/JGM.2018.15.1.43

Abstract

Partial hydatidiform mole and coexisting fetus is a rare entity with antecedent high risk of maternal and fetal complications, and risk of persistent trophoblastic disease in later life. Here, we report a case of twin pregnancy with live fetus identified as 45,X and normal placenta and another partial mole. Ultrasound scan at 10 weeks showed a hydrops fetus with a focal area of multicystic placenta. The patient underwent chorionic villus sampling and amniocentesis for chromosomal analysis, and the result was 45,X. Based on these finding, the patient then underwent induced abortion. Pathological examination (immunohistochemical staining) of the placenta confirmed the partial mole. This report suggests that careful prenatal ultrasonography and appropriate karyotyping in a molar pregnancy and coexisting fetus enable early diagnosis and may be beneficial for prognosis.

Keyword

Hydatidiform mole; Twins; Ultrasonography; Karyotyping

MeSH Terms

Abortion, Induced
Amniocentesis
Chorionic Villi Sampling
Early Diagnosis
Edema
Female
Fetus*
Humans
Hydatidiform Mole*
Karyotyping
Molar*
Placenta
Pregnancy
Pregnancy, Twin
Prognosis
Trophoblasts
Turner Syndrome*
Twins
Ultrasonography
Ultrasonography, Prenatal