Ann Dermatol.  2019 Feb;31(1):106-107. 10.5021/ad.2019.31.1.106.

A Case of Ochronosis with Atypical Manifestations Involving the Perioral Area and Sclera

• Lee MY
• Yun SJ
• Lee SC
• Won YH
• Lee JB

• KMID: 2430815
• DOI: http://doi.org/10.5021/ad.2019.31.1.106

Abstract

No abstract available.

MeSH Terms

Ochronosis*
Sclera*

Figure

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  Fig. 1 Asymptomatic dark brownish ill-defined patches around the perioral area (A), and hyperpigmentation of both sclerae (B: right eye, C: left eye).

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  Fig. 2 (A) Histopathological examination shows amorphous brownish banana-shaped fibers in the dermis. No specific findings in the epidermis (H&E, ×200). (B) Immunohistochemical staining reveals negative results with Periodic acid-Schiff (×200), and (C) ferric acid stain negative (×40).

Reference

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2. Khaled A, Kerkeni N, Hawilo A, Fazaa B, Kamoun MR. Endogenous ochronosis: case report and a systematic review of the literature. Int J Dermatol. 2011; 50:262–267.

3. Levin CY, Maibach H. Exogenous ochronosis. An update on clinical features, causative agents and treatment options. Am J Clin Dermatol. 2001; 2:213–217.

4. Skorin L Jr, Turpin S. Minocycline-induced hyperpigmentation of the skin, sclera, and palpebral conjunctiva. Can J Ophthalmol. 2017; 52:e79–e81.