Korean Lepr Bull.  2018 Dec;51(1):23-28. 10.33161/klb.2018.51.1.23.

New patient of Hansen's disease in young Korean man

• Park JM
• Kim JP
• Kang KH

• KMID: 2429660
• DOI: http://doi.org/10.33161/klb.2018.51.1.23

Abstract

Hansen's disease (leprosy) is a chronic infectious disease caused by Mycobacterium leprae which affect mainly skin and nerve systems. Currently the incidence of leprosy reached the goals set by WHO in the year 2000. In recent 10 years, only 47 new patients were found in Koreans and their average age was over 70. A 21 year-old young man showed multiple erythematous papules, macules and plaque at face, extremities and trunk. In family history, his grandfather was diagnosed with leprosy at young age and leprosy was recurred when the patient was 7 years old. The patient lived with grandfather from birth to 7 years old. Clinico-pathologically he was diagnosed with a lepromatous leprosy. We performed VNTR both at the skin tissue of grandfather and patient to find out the infection pathway of the patient and found some consistent. Herein, we report a new case of young Korean male transmitted from grandfather.

Keyword

Hansen's disease; Lepromatous leprosy; Variable number tandem repeats

MeSH Terms

Communicable Diseases
Extremities
Grandparents
Humans
Incidence
Leprosy*
Leprosy, Lepromatous
Male
Minisatellite Repeats
Mycobacterium leprae
Parturition
Skin

Figure

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  Fig. 1 Fig. 1A. Grenz zone in the upper dermis, dense peri-neurovascular cellular infiltration at the upper and lower dermis (H&E ×100). Fig. 1B. Lymphocytic infiltration and macrophages containing foamy and vacuolated cytoplasm(H&E ×200). Fig. 1C. Acid-fast bacilli stain positive at the dermis(×400).

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  Fig. 2 Multiple bilateral and symmetrical erythematous papular macules, nodules and patches at both palm and trunk. Some papules, nodules and patches at arm and leg.

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  Fig. 3 Fig. 3A. Grenz zone in the upper dermis. Extensive cellular infiltrate in the upper and lower dermis (H&E ×100). Fig. 3B. Mass of macrophages in the dermis (H&E ×200). Fig. 3C. Acid-fast bacilli stain positive at the dermis (×400).

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