Korean J Sports Med.  2018 Jun;36(2):77-83. 10.5763/kjsm.2018.36.2.77.

Effect of Remote Ischemic Preconditioning on Maximal Exercise Tolerance in Young Adults

• Yoon ES
• Jae SY

• KMID: 2429180
• DOI: http://doi.org/10.5763/kjsm.2018.36.2.77

Abstract

PURPOSE
Remote ischemic preconditioning (RIPC), induced by repeated bouts of ischemia followed by reperfusion of the arm or leg is a noninvasive strategy to protect a target organ against oxidative stress and injury caused by ischemia and reperfusion. Interestingly, recent evidence suggests that RIPC may also improve exercise performance by increasing maximal oxygen consumption, but such finding remain equivocal. As such, the purpose of the study was to examine the effect of RIPC on exercise performance in healthy individuals.
METHODS
In a randomized cross-over design, 17 healthy male participants (age, 23±3 years) were exposed to either a sham control (six cycles of 5 minutes bilateral thigh cuff occlusion at 20 mm Hg) or RIPC (six cycles of 5 minutes bilateral thigh cuff occlusion at 180 mm Hg) an hour before a maximal exercise test. We measured maximal oxygen consumption, power output, heat rate, blood pressure, and blood lactate as exercise performance parameters during a maximal exercise test performed on an upright bicycle.
RESULTS
Compared with the sham control, RIPC improved maximal oxygen consumption (7.4%, p=0.025) and maximal power output (11.5%, p=0.010), whereas other exercise performance parameters remained unchanged with RIPC (p>0.05).
CONCLUSION
Taken together, the improvements in maximal oxygen consumption and maximal power output induced by RIPC may suggest that RIPC should be considered as a method for improving exercise performance.

Keyword

Blood circulation; Exercise tolerance; Ischemic preconditioning; Oxygen consumption

MeSH Terms

Arm
Blood Circulation
Blood Pressure
Cross-Over Studies
Exercise Test
Exercise Tolerance*
Hot Temperature
Humans
Ischemia
Ischemic Preconditioning*
Lactic Acid
Leg
Male
Methods
Oxidative Stress
Oxygen Consumption
Reperfusion
Thigh
Young Adult*
Lactic Acid

Figure

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  Fig. 1 Experimental design. RIPC: remote ischemic preconditioning, CON: control, RL: right leg, LL: left leg, HR: heart rate.

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  Fig. 2 Mean and individual maximal oxygen consumption during the maximal exercise test without and with ischemic preconditioning. Control, 36.45±4.06 mL/kg/min; RIPC, 39.20±5.06 mL/kg/min. RIPC: remote ischemic preconditioning.

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