Ann Dermatol.  2018 Dec;30(6):758-760. 10.5021/ad.2018.30.6.758.

A Case of Extramammary Paget's Disease Simultaneous Occurrence with Malignant Melanoma on the Genital Area

Affiliations
  • 1Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2Department of Dermatology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea. ostksy@yahoo.co.kr

Abstract

No abstract available.


MeSH Terms

Melanoma*
Paget Disease, Extramammary*

Figure

  • Fig. 1 Multiple, variable sized, erythematous to skin colored nodules with black pigmented plaques and patches at the base of his scrotum and pubic area (A, B).

  • Fig. 2 Histopathology showed distinct patterns in extramammary Paget's disease (A) and malignant melanoma (D). Immunohistochemical staining showed that these tumor cells were strongly and diffusely positive for cytokeratin 7 (CK7), anti-human melanoma black 45 (HMB-45), Melan A and S-100 (A, D: H&E, ×200; B: CK7, ×200; C: HMB-45, ×200; E: Melan A, ×200; F: S-100, ×200).


Reference

1. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J Clin Pathol. 2000; 53:742–749.
Article
2. Kim SA, Kwon JI, Jung HR, Lee KS, Cho JW. Primary extramammary Paget's disease combined with Bowen's disease in vulva. Ann Dermatol. 2011; 23:Suppl 2. S222–S225.
Article
3. Jang EJ, Bae YK, Shin DH, Lee DJ. Extramammary Paget's disease combined with squamous cell carcinoma in situ of the vulva: a case report and differential diagnosis. Ann Dermatol. 2016; 28:497–498.
Article
4. Hill SJ, Berkowitz R, Granter SR, Hirsch MS. Pagetoid lesions of the vulva: a collision between malignant melanoma and extramammary Paget disease. Int J Gynecol Pathol. 2008; 27:292–296.
5. De la Garza Bravo MM, Curry JL, Torres-Cabala CA, Ivan DS, Drucker C, Prieto VG, et al. Pigmented extramammary Paget disease of the thigh mimicking a melanocytic tumor: report of a case and review of the literature. J Cutan Pathol. 2014; 41:529–535.
Article
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr