Psychiatry Investig.  2018 Jul;15(7):701-709. 10.30773/pi.2018.02.26.

Higher Prevalence of Hypertension among Individuals with Restless Legs Syndrome: A Meta-Analysis

Affiliations
  • 1Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
  • 2Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea. kangsg@gachon.ac.kr
  • 3Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

Abstract


OBJECTIVE
This study investigated the proposed association between restless legs syndrome (RLS) and the prevalence of hypertension.
METHODS
A meta-analysis was conducted based on searches of the PUBMED, EMBASE, Cochrane Library, and Korean electronic databases. Cohort and cross-sectional studies reporting the incidence of hypertension in individuals with RLS were included. Dichotomous data were pooled to obtain an odds ratio (OR) and 95% confidence interval (CI) for the prevalence of hypertension in individuals with RLS. The main outcome measure of the study was prevalence of hypertension in patients with RLS compared with a control group.
RESULTS
One cohort study and eight cross-sectional studies were included in the meta-analysis. Individuals with RLS had an increased prevalence of hypertension (all studies: OR=1.13, 95% CI=1.04-1.23; cross-sectional studies: OR=1.12, 95% CI=1.01-1.24). However, in subgroup analyses controlling for cardiovascular risk factors, such as diabetes mellitus and dyslipidemia, the differences in the prevalence of hypertension between RLS and control patients were no longer significant.
CONCLUSION
Patients with RLS may have a higher prevalence of hypertension, according to a pooled analysis, but the results remain to be confirmed in well-designed prospective studies.

Keyword

Restless legs syndrome; Hypertension; Prevalence; Meta-analysis

MeSH Terms

Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus
Dyslipidemias
Humans
Hypertension*
Incidence
Odds Ratio
Outcome Assessment (Health Care)
Prevalence*
Prospective Studies
Restless Legs Syndrome*
Risk Factors
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