Yonsei Med J.  2003 Oct;44(5):939-942.

An Unusual Combination of Relapsing and Cholestatic Hepatitis A in Childhood

• Ertekin V
• Selimoglu
• Orbak Z

Abstract

Clinical variants of hepatitis A include the prolonged, relapsing and cholestatic forms. Here, the first childhood case of hepatitis A, with a combination of the relapsing and cholestatic forms is presented, a 14-year old boy. In the first phase of the illness, while the AST and ALT levels were declined, th total and direct bilirubin and GGT were increased. The patient was thought to have the cholestatic form of hepatitis A. Du to intense pruritus and high bilirunbin levels, ursodeoxycholic acid (UDCA) therapy was started. On the 17th day, the decreased AST and ALT levels began to increase, reaching levels as high as 484 U/L and 862 U/L, respectively. The UDCA treatment was stopped on the 64th day. On the 164th day, all his laboratory parameters were within normal limits, but the anti-HAV IgM was still positive.

Keyword

Relapsing and cholestatic hepatitis A; childhood

MeSH Terms

Adolescent
Alanine Transaminase/blood
Aspartate Aminotransferases/blood
Cholestasis/classification/drug therapy/*etiology
Hepatitis A/*complications
Human
Male
Ursodeoxycholic Acid/therapeutic use