Korean J Helicobacter Up Gastrointest Res.
2018 Dec;18(4):247-257. 10.7704/kjhugr.2018.18.4.247.
Change in the Prevalences and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in Korea: Multicenter Clinical Trials
- Hwang YJ
- Kim N
- Kim SE
- Baik GH
- Lee JY
- Park KS
- Joo YE
- Myung DS
- Kim HJ
- Song HJ
- Kim HU
- Nam K
- Shin JE
- Kim HJ
- Kim GH
- Lee J
- Lim SH
- Seo GS
- Choi SC
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. nayoungkim49@empas.com
- 2Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
- 3Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea.
- 4Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
- 5Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 6Department of Family Medicine, Jeju National University School of Medicine, Jeju, Korea.
- 7Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
- 8Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 9Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
- 10Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
- 11Department of Internal Medicine, Seoul National University Healthcare System Gangnam Center and Healthcare Research Institute, Seoul, Korea.
- 12Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
- KMID: 2428013
- DOI: http://doi.org/10.7704/kjhugr.2018.18.4.247
Abstract
- BACKGROUND/AIMS
The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016~2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016~2017.
MATERIALS AND METHODS
A total of 4,023 subjects in 2011 and 2,506 subjects in 2016~2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed.
RESULTS
The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016~2017 (51.6%; 1,293/2,506; P < 0.001). The prevalence of AG decreased from 2011 to 2016~2017 (P=0.018), but that of IM increased (P < 0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016~2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016~2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level.
CONCLUSIONS
The difference in prevalence trends of AG and IM between 2016~2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection.
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