Investig Clin Urol.  2016 Sep;57(5):330-335. 10.4111/icu.2016.57.5.330.

Second primary cancers in patients with urothelial cancers

• Åžahin AF
• Altok M
• Akdeniz F
• Yıldız G
• Divrik RT

• KMID: 2427011
• DOI: http://doi.org/10.4111/icu.2016.57.5.330

Abstract

PURPOSE
To investigate the second primary cancers (SPCs) in patients with urothelial cancer (UC).
MATERIALS AND METHODS
The records of 2,339 patients whose UC was diagnosed between January 1974 and December 2012 were reviewed. All data about characteristics of patients, of UC and, of SPC was, recorded digitally. We investigated the prevalence and the type of second or higher order cancers, and the factors associated with SPC.
RESULTS
Total 260 patients (11.1%) had SPC, 14 had a third primary cancer and one had a fourth primary cancer. The most common SPC with UC was lung cancer (29.6%). Of all 260 with SPC, 64 (24.6%) had synchronous (within the 6 months) SPC, 120 (46.2%) had subsequent SPC and, 76 (29.2%) had antecedent SPC. The mean duration of SPC was 56 months in patients with subsequent SPC and 75.8 months in patients with antecedent SPC. The mean age at the time of diagnosis of UC was higher in patients with SPC. The ratio of male gender, body mass index, blood type, status of smoking and, occupational risk was similar in both groups. Total amount of smoking and the mean follow-up were higher in patients with SPC.
CONCLUSIONS
The majority of the patients with UC have long life expectancy. In patients with UC, the risk of having another cancer is quite higher than normal population. The physicians managing patients with UC should look for SPC.

Keyword

Multiple primary neoplasms; Second primary neoplasms; Urothelial neoplasms

MeSH Terms

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Lung Neoplasms/epidemiology/pathology
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neoplasms, Second Primary/*epidemiology/pathology
Prevalence
Retrospective Studies
Sex Factors
Turkey/epidemiology
Urologic Neoplasms/*epidemiology/pathology
Young Adult

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