J Korean Med Assoc.  2018 Nov;61(11):655-661. 10.5124/jkma.2018.61.11.655.

Recent advances of basal cell carcinoma, squamous cell carcinoma, and carcinoma in situ

• Park K

• KMID: 2426475
• DOI: http://doi.org/10.5124/jkma.2018.61.11.655

Abstract

Incidence of basal and squamous cell carcinoma is increasing among Korean. With increasing this incidence we need to attend the management and prevention of these cutaneous malignancies. Basal cell carcinoma (BCC) is the most common skin malignancy. Sun exposure is the most important environmental cause of BCC. Daily sun protection especially avoiding sun exposure between 10 a.m. and 4 p.m. provides most effective prevention against chronic ultraviolet-induced skin damage. Hedgehog pathway inhibitors are used locally advanced and metastatic BCC lesions in Korea. Until recently, there are no reports whether it developed resistance of Hedgehog pathway inhibitors with advanced BCC in Korean patients. Among malignant skin tumors, 19.1% were squamous cell carcinoma (SCC). The incidence of SCC was rapidly increased over the past years. However, the incidence rate of SCC in Japan has not been changed from the period 1976-1980 to 1986-1990. Sentinel lymph node biopsy for SCC did not provide diagnostic value. Bowen's disease and Erythroplasia of Queyrat are considered as carcinoma in situ of the skin. Erythroplasia of Queyrat have worse prognosis with a higher rate of malignant degeneration. Dermoscopy may helpful tool in assisting the noninvasive diagnosis of carcinoma in situ of the skin.

Keyword

Carcinoma, basal cell; Carcinoma, squamous cell; Bowen's disease; Erythroplasia of Queyrat; Treatment

MeSH Terms

Bowen's Disease
Carcinoma in Situ*
Carcinoma, Basal Cell*
Carcinoma, Squamous Cell*
Dermoscopy
Diagnosis
Epithelial Cells*
Erythroplasia
Hedgehogs
Humans
Incidence
Japan
Korea
Prognosis
Sentinel Lymph Node Biopsy
Skin
Solar System

Figure

• 

  Figure 1 Treatments of patients with positive margins of low-risk and high-risk basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). SE, surgical excision; MMS, Mohs microscopic surgery; RT, radiation therapy; HPIs, hedgehog pathway inhibitors. a)Exception: low-risk lesions of the trunk and extremities (excluding pretibia, hands, and feet) can be treated with repeated standard excision with postoperative margin assessment. Adapted from Mendez BM et al. Plast Reconstr Surg 2018;142:373e-387e [19].

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