Cancer Res Treat.  2018 Oct;50(4):1388-1395. 10.4143/crt.2017.162.

Projection of Breast Cancer Burden due to Reproductive/Lifestyle Changes in Korean Women (2013-2030) Using an Age-Period-Cohort Model

• Lee JE
• Lee SA
• Kim TH
• Park S
• Choy YS
• Ju YJ
• Park EC

• KMID: 2424810
• DOI: http://doi.org/10.4143/crt.2017.162

Abstract

PURPOSE
The aim of this study was to estimate the burden of breast cancer that can be attributed to rapid lifestyle changes in South Korea in 2013-2030.
MATERIALS AND METHODS
An age-period-cohort model was used to estimate the incidence and mortality. The Global Burden of Disease Study Group methodwas used to calculate the years of life lost and years lived with disability in breast cancer patients using a nationwide cancer registry. The population attributable riskswere calculated using meta-analyzed relative risk ratios and by assessing the prevalence of risk factors.
RESULTS
Women's reproductive/lifestyle changes, including advanced maternal age at first childbirth (from 37 to 85 disability-adjusted life years [DALYs] per 100,000 person-years), total period of breastfeeding (from 22 to 46 DALYs per 100,000 person-years), obesity (from 37 to 61 DALYs per 100,000 person-years), alcohol consumption (from 19 to 39 DALYs per 100,000 person-years), oral contraceptive use (from 18 to 27 DALYs per 100,000 person-years), and hormone replacement therapy use (from 2 to 3 DALYs per 100,000 person-years) were identified as factors likely to increase the burden of breast cancer from 2013 to 2030. Approximately, 34.2% to 44.3% of the burden of breast cancer could be avoidable in 2030 with reduction in reproductive/lifestyle risk factors.
CONCLUSION
The rapid changes of age structure and lifestyle in South Korea during the last decade are expected to strongly increase the breast cancer burden over time unless the risk factors can be effectively modified.

Keyword

Breast neoplasms; Lifestyle; Republic of Korea; Risk factors

MeSH Terms

Alcohol Drinking
Breast Feeding
Breast Neoplasms*
Breast*
Female
Hormone Replacement Therapy
Humans
Incidence
Korea
Life Style
Maternal Age
Mortality
Obesity
Odds Ratio
Parturition
Prevalence
Republic of Korea
Risk Factors

Figure

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  Fig. 1. Projected age-specific incidence rates of breast cancer per 100,000 women in South Korea from 2000 to 2030.

• 

  Fig. 2. Projected age-specific mortality rates of breast cancer per 100,000 women in South Korea from 2000 to 2030.

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  Fig. 3. Projected disability-adjusted life years (DALYs), years of life lost (YLL), and years lived with disability (YLD) trends of breast cancer in Korean women from 1999 to 2030.

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  Fig. 4. Projected burden of breast cancer attributable to lifestyle changes (disability-adjusted life years [DALYs] per 100,000 women).

Reference

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