Cancer Res Treat.  2018 Oct;50(4):1316-1323. 10.4143/crt.2017.575.

Breast Conservation Therapy Versus Mastectomy in Patients with T1-2N1 Triple-Negative Breast Cancer: Pooled Analysis of KROG 14-18 and 14-23

• Kim K
• Park HJ
• Shin KH
• Kim JH
• Choi DH
• Park W
• Ahn SD
• Kim SS
• Kim DY
• Kim TH
• Kim JH
• Kim J

• KMID: 2424803
• DOI: http://doi.org/10.4143/crt.2017.575

Abstract

PURPOSE
The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) versus mastectomy for patients with pT1-2N1 triple-negative breast cancer (TNBC).
MATERIALS AND METHODS
Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) receivedwhole breast RTwith orwithoutregional nodal RT,while nonewho underwent mastectomy (n=108)received it. All patients received taxane-based adjuvant chemotherapy. The median follow-up periods were 65 months in the BCS+RT group, and 74 months in the mastectomy group.
RESULTS
The median age of all patients was 48 years (range, 24 to 70 years). Mastectomy group had more patients with multiple tumors (p < 0.001), no lymphovascular invasion (p=0.001), higher number of involved lymph node (p=0.028), and higher nodal ratio ≥ 0.2 (p=0.037). Other characteristics were not significantly different between the two groups. The 5-year locoregionalrecurrence-free, disease-free, and overall survivalrates of BCS+RT group versus mastectomy group were 94.6% versus 87.7%, 89.5% versus 80.4%, and 95.0% versus 87.8%, respectively, and the differences were statistically significant after adjusting for covariates (p=0.010, p=0.006, and p=0.005, respectively).
CONCLUSION
In pT1-2N1 TNBC, breast conservation therapy achieved better locoregional recurrencefree, disease-free, and overall survival rates compared with mastectomy.

Keyword

Triple negative breast neoplasms; Breast conservation therapy; Mastectomy

MeSH Terms

Breast Neoplasms
Breast*
Chemotherapy, Adjuvant
Follow-Up Studies
Humans
Lymph Nodes
Mastectomy*
Mastectomy, Segmental
Radiotherapy
Retrospective Studies
Survival Rate
Triple Negative Breast Neoplasms*

Figure

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  Fig. 1. Locoregional recurrence-free survival (A), disease-free survival (B), and overall survival (C) curves according to the treatment. BCS, breast conserving surgery; RT, radiotherapy.

Reference

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