J Clin Neurol.  2018 Oct;14(4):594-595. 10.3988/jcn.2018.14.4.594.

Effect of Levetiracetam Monotherapy on Liver Enzymes and Creatine Kinase Concentrations in Children with Epilepsy: A Prospective Study

Affiliations
  • 1Third Department of Pediatrics, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece. attilakos@hotmail.com
  • 2Second Department of Pediatrics, National and Kapodistrian University of Athens, “P&A Kyriakou” Children's Hospital, Athens, Greece.

Abstract

No abstract available.


MeSH Terms

Child*
Creatine Kinase*
Creatine*
Epilepsy*
Humans
Liver*
Prospective Studies*
Creatine
Creatine Kinase

Reference

1. Lyseng-Williamson KA. Levetiracetam: a review of its use in epilepsy. Drugs. 2011; 71:489–514. PMID: 21395360.
2. Sethi NK, Sethi PK, Torgovnick J, Arsura E, Cukierwar F. Asymptomatic elevation of liver enzymes due to levetiracetam: a case report. Drug Metabol Drug Interact. 2013; 28:123–124. PMID: 23420283.
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3. Shahbaz N, Younus SM, Khan SA, Ain Q, Khan MA, Memon MH. Levetiracetam induced increase in creatine phosphokinase levels. J Coll Physicians Surg Pak. 2017; 27:S63–S64. PMID: 28302251.
4. Broli M, Provini F, Naldi I, Bisulli F, Sama C, Baruzzi A, et al. Unexpected gamma glutamyltransferase rise increase during levetiracetam monotherapy. Epileptic Disord. 2010; 12:81–82. PMID: 20159672.
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5. Hakami T, O'Brien TJ, Petty SJ, Sakellarides M, Christie J, Kantor S, et al. Monotherapy with levetiracetam versus older AEDs: a randomized comparative trial of effects on bone health. Calcif Tissue Int. 2016; 98:556–565. PMID: 26842957.
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6. Xiong N, Hou L, Lu N, Mohamed AA, Wang T, Huang Y. Probable levetiracetam-related serum alkaline phosphatase elevation. BMC Neurol. 2012; 12:97. PMID: 22994584.
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