Nucl Med Mol Imaging.  2018 Oct;52(5):334-341. 10.1007/s13139-018-0542-9.

Inverse Prognostic Relationships of ¹⁸F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

• Yi HK
• Park YJ
• Bae JH
• Lee JK
• Lee KH
• Choi SH
• Lee KH
• Kim BT
• Choi JY

• KMID: 2422794
• DOI: http://doi.org/10.1007/s13139-018-0542-9

Abstract

PURPOSE
As there were few previous studies with a small number of subjects, the purpose of this was to evaluate the prognostic significance of ¹â¸F-FDG PET/CT in patients with distal bile duct cancer undergoing curative surgery.
METHODS
The study included 40 patients (M/F = 24:16; age 68.0 ± 8.0 years) who underwent preoperative ¹â¸F-FDG PET/CT followed by curative surgical resection. The participant's age, sex, Eastern Cooperative Oncology Group performance-status score, baseline serum CA 19-9 level, stage, pathologic T and N stages, tumor size, tumor grade, tumor growth pattern, R0 resection, and adjuvant therapy were included as clinicopathological variables for predicting overall survival. The PET variables were maximum standardized uptake value (SUV(max)), average SUV (SUV(avg)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the tumor. The Kaplan-Meyer method and Cox proportional hazards model were used for the survival analysis.
RESULTS
A total of 15 of 40 patients (37.5%) died during the follow-up period. In univariate analysis, low SUVmax (≤ 2.7, p = 0.0005) and low SUV(avg) (≤ 2.6, p = 0.0034) were significant predictors of poor overall survival. In multivariate analyses, only low SUV(max) (HR = 6.7016, 95% CI 1.9961-22.4993, p = 0.0047) was an independent prognostic factor associated with poor overall survival.
CONCLUSION
The SUVmax of the primary tumor measured by ¹â¸F-FDG PET/CT was an independent significant prognostic factor for overall survival in patients with distal bile duct cancer. However, different results from a previous study warrant further large sample-sized study.

Keyword

Cholangiocarcinoma; Distal bile duct cancer; ¹⁸F-FDG; PET; Prognosis

MeSH Terms

Bile Duct Neoplasms*
Bile Ducts*
Bile*
Cholangiocarcinoma
Follow-Up Studies
Glycolysis
Humans
Methods
Multivariate Analysis
Positron-Emission Tomography and Computed Tomography*
Prognosis
Proportional Hazards Models
Tumor Burden