Int Neurourol J.  2018 Sep;22(3):185-191. 10.5213/inj.1836050.025.

Specificity of Lower Urinary Tract Symptoms in Neuromyelitis Optica in Comparison With Multiple Sclerosis Patients

• Declemy A
• Chesnel C
• Charlanes
• Le Breton
• Ismael SS
• Amarenco G

• KMID: 2422506
• DOI: http://doi.org/10.5213/inj.1836050.025

Abstract

PURPOSE
The aim of this study was to describe lower urinary tract symptoms in neuromyelitis optica (NMO), and to compare these data with urinary disorders observed in multiple sclerosis (MS) patients.
METHODS
Retrospective study of data collected from January 1997 to July 2017 using the database from a Neuro-Urology Department of a university hospital. NMO and MS patients were matched for sex, age, and Expanded Disability Status Scale (EDSS)
RESULTS
Twenty-six patients with NMO were included and compared with 33 MS patients. Mean age was 41.6 years (standard deviation [SD], 14,8), mostly female patients (24 vs. 2 males). Mean EDSS was 4.6 (SD, 1.8) in the 2 groups. In NMO group, 57% of the patients (n=15) had overactive bladder with urgency and urge incontinence and 38.5% (n=10) of them had nocturia. Voiding symptoms was observed in 69.2% of the patients (n=18); 42.3% of NMO patients performed self-intermittent catheterization versus 12.1% in MS patients (P=0.012). Low bladder compliance and severe urinary tract infections (pyelonephritis) were more frequent in NMO than in MS patients (respectively 15% vs. 0%, P=0.016 and 42% vs. 12%, P=0.024).
CONCLUSIONS
Lower urinary tract symptoms, especially overactive bladder and urinary retention, are frequent in NMO. Low bladder compliance, serious urinary infections, and high prevalence of urinary retention requiring self-intermittent catheterization are the main symptoms significantly more frequent than in MS.

Keyword

Devic disease; Neuromyelitis optica; Multiple sclerosis; Lower urinary tract symptoms; Voiding disorder

MeSH Terms

Catheterization
Catheters
Compliance
Female
Humans
Lower Urinary Tract Symptoms*
Multiple Sclerosis*
Neuromyelitis Optica*
Nocturia
Prevalence
Retrospective Studies
Sensitivity and Specificity*
Urinary Bladder
Urinary Bladder, Overactive
Urinary Incontinence, Urge
Urinary Retention
Urinary Tract Infections