Endocrinol Metab.  2018 Jun;33(2):211-218. 10.3803/EnM.2018.33.2.211.

Association between Bone Mineral Density and Albuminuria: Cross-Sectional Analysis of Data from the 2011 Korea National Health and Nutrition Examination Survey V-2

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. cgchomd@naver.com
  • 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
  • 3Department of Public Health, Wonkwang University School of Medicine, Iksan, Korea.
  • 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea. drhormone@naver.com

Abstract

BACKGROUND
Albuminuria is known to be independently associated with progression of renal and cardiovascular disease. However, little is known regarding the exact relationship between albuminuria and bone mineral density (BMD). The aim of this population-based study conducted in Korea was to identify the association between albuminuria and BMD.
METHODS
We performed a cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey (KNHANES V-2) 2011. BMD was measured for total hip (TH), femur neck (FN), and lumbar spine (LS). Analysis of covariance was used to compare BMD levels between the groups at the TH, FN, and LS sites, after adjusting for age. Separate analyses were performed according to sex; women were divided into two groups according to menopausal status and each group was subdivided into three according to urine albumin-to-creatinine ratio (level 1, <30 mg/g; level 2, 30 to 299 mg/g; level 3, ≥300 mg/g).
RESULTS
Data on a total of 1,831 adults (857 men and 974 women) were analyzed. In postmenopausal women, after adjusting for age, BMD of TH tended to decrease as levels of albuminuria increased (0.767±0.117, 0.757±0.129, 0.752±0.118, respectively; P=0.040). However, there was no significant difference in BMD according to albuminuria level in premenopausal women and men.
CONCLUSION
Level of albuminuria was closely related with BMD of TH in postmenopausal women, after adjusting for age, but there was no significant relationship between albuminuria and BMD in premenopausal women and men.

Keyword

Albuminuria; Bone density; Metabolic syndrome; Osteoporosis, postmenopausal

MeSH Terms

Adult
Albuminuria*
Bone Density*
Cardiovascular Diseases
Cross-Sectional Studies*
Female
Femur Neck
Hip
Humans
Korea*
Male
Nutrition Surveys*
Osteoporosis, Postmenopausal
Spine

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