Clin Psychopharmacol Neurosci.  2018 Aug;16(3):358-360. 10.9758/cpn.2018.16.3.358.

Ventricular Arrhythmia during Tracheal Intubation and Extubation under General Anesthesia Possibly Induced by Amisulpride: A Case Report

• Fang B
• Ma H

• KMID: 2419993
• DOI: http://doi.org/10.9758/cpn.2018.16.3.358

Abstract

We are presenting the first documented case of amisulpride related ventricular arrhythmia during tracheal intubation and extubation under general anesthesia in an 48 year-old female with psychiatric history of chronic schizophrenia who was treated with amisulpride. This case suggests the threshold of perioperative arrhythmia is possibly decreased in patients with long-term antipsychotic medication. So, the potential risk of antipsychotics-induced perioperative arrhythmia should be evaluated, as well as heart rhythm monitoring, prophylactic use of antiarrhythmic drugs, and preoperative adjustment of antipsychotics should be considered.

Keyword

Amisulpride; Ventricular arrhythmia; Intubation; intratracheal

MeSH Terms

Anesthesia, General*
Anti-Arrhythmia Agents
Antipsychotic Agents
Arrhythmias, Cardiac*
Female
Heart
Humans
Intubation*
Schizophrenia
Anti-Arrhythmia Agents
Antipsychotic Agents