Psychiatry Investig.  2018 Aug;15(8):824-828. 10.30773/pi.2018.04.03.2.

Higher Serum C Reactive Protein Determined C Reactive Protein Single-Nucleotide Polymorphisms Are Involved in Inherited Depression

• Wang S
• Zhong H
• Lu M
• Song G
• Zhang X
• Lin M
• Yang S
• Qian M

• KMID: 2419373
• DOI: http://doi.org/10.30773/pi.2018.04.03.2

Abstract

OBJECTIVE
The pathogenesis of depression is not fully understood yet, but studies have suggested higher circulating C reactive protein (CRP) level might relate to depression occurrence. However, due to high variability of patients' individual condition, the results to date are inconsistent. Considering CRP single-nucleotide polymorphisms (SNPs) could also regulate plasma CRP levels, in the present study, we hypothesized that inherited CRP allelic variations may co-vary with depressive symptomatology.
METHODS
We recruited 60 depression patients with family depression history and 60 healthy control volunteers into this project. We detected circulation CRP level as well as genome CRP SNPs from participants of this project.
RESULTS
We have found a significantly higher circulating CRP level in patients with a positive family history. Furthermore, we also identified some certain inherited CRP SNPs (A allele in rs1417938 and C allele in rs1205) could up regulate serum CRP level and distributed more in depression patients with family history.
CONCLUSION
Our finding may raise new evidence that genetically increased serum CRP level through SNPs variation is likely to induce family inherited depression.

Keyword

CRP; Depression; SNPs; Familial inheritance

MeSH Terms

Alleles
C-Reactive Protein*
Depression*
Genome
Humans
Plasma
Polymorphism, Single Nucleotide
Volunteers
C-Reactive Protein