J Korean Neurosurg Soc.  2018 Jul;61(4):467-473. 10.3340/jkns.2017.0505.006.

Endovascular Treatment with Intravenous Thrombolysis versus Endovascular Treatment Alone for Acute Anterior Circulation Stroke : A Meta-Analysis of Observational Studies

• Kim CH
• Jeon JP
• Kim SE
• Choi HJ
• Cho YJ

• KMID: 2417322
• DOI: http://doi.org/10.3340/jkns.2017.0505.006

Abstract

OBJECTIVE
The aim of this study was to determine outcome of ischemic stroke patients in the anterior circulation treated with endovascular treatment (EVT) with intravenous thrombolysis (IVT) versus EVT alone group.
METHODS
A systemic literature review was performed using online database from January 2004 to January 2017. Primary outcomes were successful recanalization seen on finial angiography and good outcome at three months. Secondary outcomes were mortality and the development of symptomatic intracranial hemorrhage (S-ICH) after the procedure. A fixed effect model was used when heterogeneity was less than 50%. Egger's regression test was used to assess publication bias.
RESULTS
Five studies were included for final analysis. Between EVT with IVT and EVT alone group, successful recanalization (odds ratio [OR] 1.467, p=0.216), good clinical outcome at three months (OR 1.199, p=0.385), mortality (OR 0.776, p=0.371), and S-ICH (OR 1.820, p=0.280) did not differ significantly. Egger's regression intercept with 95% confidence interval (CI) was 1.99 (95% CI -2.91 to 6.89) in successful recanalization and -0.27 (95% CI -6.35 to 5.80) in good clinical outcome, respectively.
CONCLUSION
The two treatment modalities, EVT with IVT and EVT alone, could be comparable in treating acute anterior circulation stroke. Studies to find specific beneficiary group for EVT alone, without primary IVT, are needed further.

Keyword

Thrombectomy; Stroke; Endovascular procedures; Mechanical thrombolysis

MeSH Terms

Angiography
Endovascular Procedures
Humans
Intracranial Hemorrhages
Mechanical Thrombolysis
Mortality
Population Characteristics
Publication Bias
Stroke*
Thrombectomy

Figure

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  Fig. 1. Flow chart showing the process used for the identification of relevant studies.

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  Fig. 2. Comparison of treatment outcomes between endovascular treatment (EVT) with intravenous thrombolysis (IVT) and EVT alone in terms of successful recanalization rate (A), good clinical outcomes at three months (B), mortality (C), and symptomatic intracranial hemorrhage (D). CI : confidence interval.

Reference

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