Korean J Intern Med.  2018 Jul;33(4):823-828. 10.3904/kjim.2016.065.

The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus

• Son CN
• Lee TH
• Bang JH
• Jeong HJ
• Chae JN
• Lee WM
• Kim JM
• Kim SH

• KMID: 2416010
• DOI: http://doi.org/10.3904/kjim.2016.065

Abstract

BACKGROUND/AIMS
Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE.
METHODS
This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE.
RESULTS
The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls (11.3 ± 5.6 µg/mL vs. 9.1 ± 2.8 µg/mL). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers.
CONCLUSIONS
These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.

Keyword

Systemic lupus erythematosus; Anti-C-reactive protein antibody

MeSH Terms

Antibodies
Biomarkers
Complement System Proteins
DNA
Humans
Lupus Erythematosus, Systemic*
Antibodies
Biomarkers
Complement System Proteins
DNA