J Clin Neurol.  2018 Jul;14(3):345-350. 10.3988/jcn.2018.14.3.345.

Measurement of the Optic Nerve Sheath Diameter with Magnetic Resonance Imaging and Its Association with Eyeball Diameter in Healthy Adults

• Kim DH
• Jun JS
• Kim R

• KMID: 2415051
• DOI: http://doi.org/10.3988/jcn.2018.14.3.345

Abstract

BACKGROUND AND PURPOSE
The optic nerve sheath diameter (ONSD) is an indirect marker of the intracranial pressure, but the normal range of ONSD as measured using magnetic resonance imaging (MRI) and its associations with clinical parameters and the eyeball transverse diameter (ETD) remain unclear.
METHODS
We included 314 healthy adults who underwent brain MRI examinations for health screening between June 2014 and September 2017. The ONSD and ETD of each eye were calculated using time-of-flight magnetic resonance angiography. Linear regression analyses were performed to assess the relationships between ONSD and variables including age, sex, height, weight, body mass index (BMI), mean arterial blood pressure (MABP), intraocular pressure (IOP), and ETD. We further investigated a normative value for the ONSD/ETD ratio and its associated factors.
RESULTS
The mean ONSD and ETD were 4.71 mm [95% confidence interval (CI), 4.66-4.75 mm] and 21.24 mm (95% CI, 21.13-21.35 mm), respectively. Multiple linear regression analysis showed that ONSD was only associated with ETD (p < 0.001), with it being independent of age, sex, height, weight, BMI, MABP, and IOP. The ONSD/ETD ratio had a mean value of 0.22 (95% CI, 0.22-0.22), and was not correlated with age, sex, height, weight, BMI, MABP, or IOP.
CONCLUSIONS
This study determined the normative value of MRI-based ONSD in healthy Korean adults. There was a strong correlation between the ETD and ONSD, which can be presented as the ONSD/ETD ratio. This parameter needs to be investigated further in disease populations.

Keyword

magnetic resonance imaging; optic nerve sheath diameter; eyeball transverse diameter; healthy; Korean

MeSH Terms

Adult*
Arterial Pressure
Body Weight
Brain
Humans
Intracranial Pressure
Intraocular Pressure
Linear Models
Magnetic Resonance Angiography
Magnetic Resonance Imaging*
Mass Screening
Optic Nerve*
Reference Values

Figure

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  Fig. 1 Flow diagram of subject selection.

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  Fig. 2 Sample image showing how the ONSD and ETD are estimated. ETD: eyeball transverse diameter, MRA: magnetic resonance angiography, ONSD: optic nerve sheath diameter, TOF: time-of-flight.

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