Ann Dermatol.  2018 Apr;30(2):258-261. 10.5021/ad.2018.30.2.258.

Basement Membrane Status Is Intact in Urticarial Dermatitis vs. Adult-Onset Atopic Dermatitis

• Kim TI
• Park HJ
• Won YY
• Choi H
• Jeong KH
• Sung JY
• Shin MK

• KMID: 2414701
• DOI: http://doi.org/10.5021/ad.2018.30.2.258

Abstract

No abstract available.

MeSH Terms

Basement Membrane*
Dermatitis*
Dermatitis, Atopic*

Figure

• 

  Fig. 1 Clinical features and histological findings of urticarial dermatitis (UD) and adult-onset atopic dermatitis (AD). (A) Clinical features show urticarial erythematous papules, plaques, and patches on the right flank of a patient with UD. (B) Clinical features of a patient with adult-onset AD show erythematous excoriated papules on the abdomen. (C, F) H&E staining demonstrated mild papillomatosis and perivascular lymphocytic infiltration (C: ×100, F: ×400, respectively). (D, G) H&E staining showed mixed infiltration including lymphocytes, neutrophils, and eosinophils in the perivascular area (D: ×100, G: ×400, respectively). (E, H) H&E staining presented parakeratosis and acanthosis. Dermis shows mildly dilated vessels with perivascular lymphocytic infiltration (E: ×100, H: ×400, respectively).

• 

  Fig. 2 Differences in basement membrane (BM) thickness and expression of type IV collagen and integrin α6 in normal skin, urticarial dermatitis (UD), and adult-onset atopic dermatitis (AD). (A) Periodic-acid-Schiff (PAS) staining demonstrated clear BM areas in normal skin. The UD group showed a continuous linear band of BM without discontinuity. The adult-onset AD group showed a thin linear band of BM with occasional faults and numerous strands extending into the connective tissue. Type IV collagen and integrin α6 were significantly decreased in the BM of the AD group compared with the normal and UD groups (×200; scale bar, 50 µm). (B) The mean of PAS-positive BM thickness in normal, UD, and AD groups was 1.37±0.26, 1.24±0.45, and 0.48±0.14 µm, respectively. The UD and normal groups did not show a significant difference in PAS-positive BM thickness (p=0.374). The AD group showed a significantly decreased thickness of BM compared with the normal group and UD group (p=0.01 and p<0.001, respectively). The UD and normal groups did not show significant difference in type IV collagen (p=0.539) or integrin α6 staining in the BM (p=0.839). The mean grade of staining intensity for type IV collagen in AD was 0.67±0.52, which is significantly lower than that observed in the normal (3.75±0.96) and UD (3.30±1.16) groups (p=0.01 and p<0.001, respectively). The mean grade of staining intensity for integrin α6 was 0.33±0.52 in AD, which is significantly lower than that in the normal (3.00±0.82) and UD (3.20±1.03) groups (p=0.01 and p<0.001, respectively). *p<0.05, **p<0.005.

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