J Korean Assoc Oral Maxillofac Surg.  2018 Jun;44(3):136-139. 10.5125/jkaoms.2018.44.3.136.

Angioleiomyoma of the oral cavity: a case report and brief review of the literature

• Matiakis A
• Karakostas P
• Pavlou AM
• Anagnostou E
• Poulopoulos A

• KMID: 2414433
• DOI: http://doi.org/10.5125/jkaoms.2018.44.3.136

Abstract

This study presents a case of an oral angioleiomyoma along with its clinical diagnostic approach and laboratory confirmation. The differential diagnosis, especially from angioleiomyosarcoma, is also included. A 51-year-old patient presented with a tumor-like lesion on his upper labial mucosa. The clinical examination revealed a benign lesion that was surgically removed. Histopathological and immunohistochemical examinations confirmed the diagnosis of an oral angioleiomyoma. The post-surgical period was uneventful. No recurrence had occurred after a year of follow-up surveillance. Oral angioleiomyoma is a very rarely occurring oral lesion. Clinically, it may mimic some benign lesions, including fibroma, pyogenic granuloma or minor salivary gland tumor. Surgical excision is the treatment of choice. Histological and immunohistochemical examination can confirm the diagnosis. The differential diagnosis is crucial to rule out angioleiomyosarcoma.

Keyword

Oral angioleiomyoma; Oral vascular leiomyoma; Oral leiomyoma

MeSH Terms

Angiomyoma*
Diagnosis
Diagnosis, Differential
Fibroma
Follow-Up Studies
Granuloma, Pyogenic
Humans
Middle Aged
Mouth*
Mucous Membrane
Recurrence
Salivary Glands, Minor

Figure

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  Fig. 1 Initial clinical appearance.

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  Fig. 2 Bundles of smooth muscle fibers of thick-walled blood vessels (H&E staining, ×40).

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  Fig. 3 Similar microscopic findings with no nuclear atypia or mitoses (H&E staining, ×400).

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  Fig. 4 Positive immunohistochemical reaction of the smooth muscle fibers (h-caldesmon staining, ×40).

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