Blood Res.  2018 Mar;53(1):74-78. 10.5045/br.2018.53.1.74.

A rare case of splenic diffuse red pulp small B-cell lymphoma (SDRPL): a review of the literature on primary splenic lymphoma with hairy cells

• Vig T
• Kodiatte T
• Manipadam
• Aboobacker FN

• KMID: 2414368
• DOI: http://doi.org/10.5045/br.2018.53.1.74

Abstract

No abstract available.

MeSH Terms

B-Lymphocytes*
Lymphoma*
Lymphoma, B-Cell*

Figure

• 

  Fig. 1 Peripheral blood smear showed the presence of atypical lymphoid cells with numerous circumferential hair-like processes and inconspicuous nucleoli. Inset shows a neoplastic lymphocyte with appreciable villous processes.

• 

  Fig. 2 Bone marrow trephine biopsy. (A–C) There is an interstitial and sinusoidal infiltrate due to a small lymphoid population (H&E, magnification ×100, ×400 and ×400). (D) Immunostaining for CD20 highlights the intrasinusoidal infiltrate (×40 magnification).

• 

  Fig. 3 Splenectomy specimen shows diffusely enlarged spleen with a beefy red homogenous cut surface and wedge-shaped subcapsular infarcts.

• 

  Fig. 4 Splenectomy specimen. (A–C) Diffuse red pulp and sinusoidal infiltration with obliteration of the white pulp, (H&E, magnification ×100, ×400 and ×400). Tumor cells are positive for CD20 (D) and DBA-44 (E). The MIB-1 proliferation index is very low (F).

Reference

1. Piris MA, Foucar KM, Mollejo M, Campo E, Falini B. Splenic lymphoma/leukemia, unclassifiable. In : Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumors of hematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press;2008. p. 191–193.

2. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127:2375–2390. PMID: 26980727.

3. Ponzoni M, Kanellis G, Pouliou E, et al. Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology? Am J Surg Pathol. 2012; 36:1609–1618. PMID: 23073320.

4. Behdad A, Bailey NG. Diagnosis of splenic B-cell lymphomas in the bone marrow: a review of histopathologic, immunophenotypic, and genetic findings. Arch Pathol Lab Med. 2014; 138:1295–1301. PMID: 25268192.

5. Cessna MH, Hartung L, Tripp S, Perkins SL, Bahler DW. Hairy cell leukemia variant: fact or fiction. Am J Clin Pathol. 2005; 123:132–138. PMID: 15762289.

6. Dong HY, Weisberger J, Liu Z, Tugulea S. Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Am J Clin Pathol. 2009; 131:586–595. PMID: 19289595.

7. Traverse-Glehen A, Baseggio L, Bauchu EC, et al. Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity? Blood. 2008; 111:2253–2260. PMID: 18042795.

8. Kanellis G, Mollejo M, Montes-Moreno S, et al. Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features. Haematologica. 2010; 95:1122–1129. PMID: 20220064.

9. Gujral S, Lad P, Subramanian PG, et al. Histopathological audit of splenectomies received at a cancer hospital. Indian J Pathol Microbiol. 2011; 54:487–496. PMID: 21934208.

10. Traverse-Glehen A, Baseggio L, Salles G, Coiffier B, Felman P, Berger F. Splenic diffuse red pulp small-B cell lymphoma: toward the emergence of a new lymphoma entity. Discov Med. 2012; 13:253–265. PMID: 22541613.

11. Tiacci E, Trifonov V, Schiavoni G, et al. BRAF mutations in hairy-cell leukemia. N Engl J Med. 2011; 364:2305–2315. PMID: 21663470.