Blood Res.  2017 Jun;52(2):141-143. 10.5045/br.2017.52.2.141.

Utility of an immunoglobulin gene rearrangement assay based on multiplex PCR in detecting bone marrow involvement in B-cell non-Hodgkin lymphoma

• Park DJ
• Cho HC
• Kwon JH
• Park JY

• KMID: 2413335
• DOI: http://doi.org/10.5045/br.2017.52.2.141

Abstract

No abstract available.

MeSH Terms

B-Lymphocytes*
Bone Marrow*
Genes, Immunoglobulin*
Immunoglobulins*
Lymphoma, Non-Hodgkin*
Multiplex Polymerase Chain Reaction*
Immunoglobulins

Reference

1. Lossos IS. Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol. 2005; 23:6351–6357.

2. Kang YH, Park CJ, Seo EJ, et al. Polymerase chain reaction-based diagnosis of bone marrow involvement in 170 cases of non-Hodgkin lymphoma. Cancer. 2002; 94:3073–3082.

3. Sandberg Y, van Gastel-Mol EJ, Verhaaf B, Lam KH, van Dongen JJ, Langerak AW. BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics. J Mol Diagn. 2005; 7:495–503.

4. van Krieken JH, Langerak AW, Macintyre EA, et al. Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia. 2007; 21:201–206.

5. Fey MF, Pilkington SP, Summers C, Wainscoat JS. Molecular diagnosis of haematological disorders using DNA from stored bone marrow slides. Br J Haematol. 1987; 67:489–492.

6. Odenthal M, Siebolts U, Ernestus K, Disse D, Dienes HP, Wickenhauser C. Immunoglobulin heavy chain gene analysis in bone marrow biopsies and corresponding lymph node specimens: dependency on pre-treatment, histological subtype and extension of B-cell lymphoma. Int J Mol Med. 2008; 21:569–576.

7. Abbas F, Yazbek SN, Shammaa D, Hoteit R, Fermanian P, Mahfouz R. Invivoscribe BIOMED-2 primer mixes in B-cell immunoglobulin gene rearrangement studies: experience of a molecular diagnostics laboratory in a major tertiary care center. Genet Test Mol Biomarkers. 2014; 18:787–790.

8. Cheson BD. Role of functional imaging in the management of lymphoma. J Clin Oncol. 2011; 29:1844–1854.

9. Brisco MJ, Latham S, Sutton R, et al. Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia. J Mol Diagn. 2009; 11:194–200.

10. Ghorbian S, Jahanzad I, Javadi GR, Sakhinia E. Evaluation of IGK and IGL molecular gene rearrangements according to the BIOMED-2 protocols for clinical diagnosis of Hodgkin lymphoma. Hematology. 2016; 21:133–137.

11. Shin S, Kim AH, Park J, et al. Analysis of immunoglobulin and T cell receptor gene rearrangement in the bone marrow of lymphoid neoplasia using BIOMED-2 multiplex polymerase chain reaction. Int J Med Sci. 2013; 10:1510–1517.