Gut Liver.  2017 Jul;11(4):559-566. 10.5009/gnl16284.

Comparison of Histologic Core Portions Acquired from a Core Biopsy Needle and a Conventional Needle in Solid Mass Lesions: A Prospective Randomized Trial

• Lee BS
• Cho CM
• Jung MK
• Jang JS
• Bae HI

• KMID: 2412237
• DOI: http://doi.org/10.5009/gnl16284

Abstract

BACKGROUND/AIMS
The superiority of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) over EUS-guided fine needle aspiration (EUS-FNA) remains controversial. Given the lack of studies analyzing histologic specimens acquired from EUS-FNB or EUS-FNA, we compared the proportion of the histologic core obtained from both techniques.
METHODS
A total of 58 consecutive patients with solid mass lesions were enrolled and randomly assigned to the EUS-FNA or EUS-FNB groups. The opposite needle was used after the failure of core tissue acquisition using the initial needle with up to three passes. Using computerized analyses of the scanned histologic slide, the overall area and the area of the histologic core portion in specimens obtained by the two techniques were compared.
RESULTS
No significant differences were identified between the two groups with respect to demographic and clinical characteristics. Fewer needle passes were required to obtain core specimens in the FNB group (p<0.001). There were no differences in the proportion of histologic core (11.8%±19.5% vs 8.0%±11.1%, p=0.376) or in the diagnostic accuracy (80.6% vs 81.5%, p=0.935) between two groups.
CONCLUSIONS
The proportion of histologic core and the diagnostic accuracy were comparable between the FNB and FNA groups. However, fewer needle passes were required to establish an accurate diagnosis in EUS-FNB.

Keyword

Endosonography; Tissue sampling; Core tissue; Endoscopic ultrasound-guided fine needle aspiration; Endoscopic ultrasound-guided fine needle biopsy

MeSH Terms

Adult
Aged
Aged, 80 and over
Biopsy, Large-Core Needle/methods/*statistics & numerical data
Diagnostic Techniques, Digestive System/*statistics & numerical data
Digestive System Neoplasms/*diagnosis/pathology
Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods/*statistics & numerical data
Endosonography/*methods
Female
Humans
Male
Middle Aged
Prospective Studies