Gut Liver.
2017 Jan;11(1):87-92. 10.5009/gnl15549.
Quality of Life after Endoscopic Submucosal Dissection for Early Gastric Cancer: A Prospective Multicenter Cohort Study
- Affiliations
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- 1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- 2National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.
- 3National Health Insurance Service, Seoul, Korea.
- 4Center for Gastric Cancer, National Cancer Center, Goyang, Korea.
- 5Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 6Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
- 7Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jjkim@skku.edu
- 8Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea.
- 9Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 10Digestive Disease Center, Soonchunhyang University Hospital, Seoul, Korea.
- 11Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
- 12Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
- 13Department of Internal Medicine, Institute of Digestive Diseases and Nutrition, Korea University College of Medicine, Seoul, Korea.
- 14Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 15Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2412159
- DOI: http://doi.org/10.5009/gnl15549
Abstract
- BACKGROUND/AIMS
Endoscopic submucosal dissection (ESD) has been an established treatment for indicated early gastric cancer (EGC) without deterioration of quality of life (QOL) compared with surgical resection. The aim of this study was to evaluate long-term QOL in patients undergoing ESD for EGC.
METHODS
Patients scheduled to undergo curative ESD for EGC were prospectively enrolled from 12 institutions between May 2010 and December 2011. Assessments of QOL with Korean versions of the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire-core (QLQ-C30) and a gastric cancer-specific questionnaire (STO22) were performed at baseline and at 7 days, 3 months, and 6 months after ESD.
RESULTS
A total of 666 subjects were assessed for QLQ-C30 and QLQ-STO22. The mean QLQ-C30 score was 69.5 at baseline, 68.8 at 7 days, 73.1 at 3 months, and 73.2 at 6 months. The global health status on the EORTC QLQ-C30 was significantly improved after 3 and 6 months (p=0.0003 and p<0.0001, respectively). The QLQ-C30 and STO22 scores were not significantly different, or they only slightly deteriorated between before and immediately after ESD, but they were significantly improved after 3 and 6 months (p<0.05).
CONCLUSIONS
QOL did not deteriorate immediately after ESD, and it improved more significantly at up to 6 months in patients who underwent curative ESD for EGC without significant complications.
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