Gut Liver.  2016 Nov;10(6):948-954. 10.5009/gnl15481.

The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular Carcinoma

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea. psyoung0419@gmail.com
  • 2Department of Pathology, Kyungpook National University Hospital, Daegu, Korea.
  • 3Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Korea.
  • 4BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Korea.
  • 5Biostatistics Center, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

BACKGROUND/AIMS
Periostin is an extracellular matrix protein and is known to be related to the metastatic potential and prognosis of cancer. However, few studies have investigated the expression level of periostin and its association with prognoses in hepatocellular carcinoma. Therefore, we analyzed periostin overexpression in hepatocellular carcinoma and its implication for prognoses.
METHODS
We evaluated 149 patients who underwent surgical resection between 2006 and 2010. Tissue microarrays were constructed from hepatocellular carcinoma tissue and adjacent nontumor tissue, and immunohistochemistry was performed.
RESULTS
A high periostin level was observed more frequently in cases of multiple tumors (odds ratio [OR], 2.826; 95% confidence interval [CI], 1.224 to 6.527; p=0.013), positive microvascular invasion (OR, 2.974; 95% CI, 1.431 to 6.181; p=0.003), and advanced stage disease (OR, 3.032; 95% CI, 1.424 to 6.452; p=0.003). Patients with high periostin expression had significantly (p=0.002) lower overall survival rates than those with low periostin expression (90.3%, 66.1%, and 56.2% vs 97.7%, 85.1%, and 77.5% at 1, 3, and 5 years).
CONCLUSIONS
We found that a combination of periostin overexpression and microvascular invasion in hepatocellular carcinoma was correlated with a poor prognosis and can be a good prognostic marker for hepatocellular carcinoma.

Keyword

Periostin; Microvascular invasion; Hepatocellular carcinoma; Tissue microarray analysis; Prognosis

MeSH Terms

Biomarkers, Tumor/blood
Carcinoma, Hepatocellular/blood/*pathology
Cell Adhesion Molecules/*blood
Female
Follow-Up Studies
Hepatectomy
Humans
Immunohistochemistry
Liver Neoplasms/blood/*pathology
Male
Microvessels/*pathology
Middle Aged
Neoplasm Invasiveness
Prognosis
Retrospective Studies
Survival Rate
Biomarkers, Tumor
Cell Adhesion Molecules
Full Text Links
  • GNL
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr