Gut Liver.  2016 Nov;10(6):881-889. 10.5009/gnl15414.

Potassium Channelopathies and Gastrointestinal Ulceration

• Han J
• Lee SH
• Giebisch G
• Wang T

• KMID: 2412092
• DOI: http://doi.org/10.5009/gnl15414

Abstract

Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation. In previous decades, the key revelations that potassium channels and transporters are involved in the production of gastric acid and the regulation of secretion in the stomach have been recognized. Drugs used to treat peptic ulceration are often potassium transporter inhibitors. It has also been reported that potassium channels are involved in ulcerative colitis. Direct toxicity to the intestines from nonsteroidal anti-inflammatory drugs has been associated with altered potassium channel activities. Several reports have indicated that the long-term use of the antianginal drug Nicorandil, an adenosine triphosphate-sensitive potassium channel opener, increases the chances of ulceration and perforation from the oral to anal regions throughout the gastrointestinal (GI) tract. Several of these drug features provide further insights into the role of potassium channels in the occurrence of ulceration in the GI tract. The purpose of this review is to investigate whether potassium channelopathies are involved in the mechanisms responsible for ulceration that occurs throughout the GI tract.

Keyword

Gastrointestinal tract; Ulceration; Potassium channels; H⁺/K⁺-ATPase

MeSH Terms

Animals
Anti-Arrhythmia Agents/adverse effects
*Channelopathies
Colon/metabolism
Gastrointestinal Diseases/metabolism/*pathology
Gastrointestinal Tract/metabolism/pathology
Humans
Mice
Nicorandil/adverse effects
Peptic Ulcer/metabolism/*pathology
Potassium Channels/*physiology
Ulcer/metabolism/*pathology
Anti-Arrhythmia Agents
Potassium Channels
Nicorandil