J Korean Med Sci.  2018 May;33(19):e133. 10.3346/jkms.2018.33.e133.

Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia

• Lim EY
• Yang DW
• Kim JS
• Cho AH

• KMID: 2410525
• DOI: http://doi.org/10.3346/jkms.2018.33.e133

Abstract

BACKGROUND
There are debates on representation and generalizability of previous randomized controlled trials about anti-dementia agents in the oldest old population. In this context, we aimed to investigate the efficacy and safety of anti-dementia agents in the very elderly patients with dementia.
METHODS
We conducted a retrospective study of patients with dementia 1) who were 85 years or older, 2) got started anti-dementia agents, and 3) went through follow-up evaluation about one year thereafter. As a control, patients with dementia who were less than 85 years old with similar inclusion criteria were randomly selected during the same period. The adverse drug effects and discontinuation rates were investigated with self-reported complaint after starting or increasing anti-dementia drugs. For efficacy outcome, we also analyzed the change in neuropsychological results during follow-up period.
RESULTS
A total of 77 dementia patients who were at least 85 years were enrolled. As a control group, 78 patients with dementia who were younger than 85 was analyzed. The adverse drug effects were observed in 26 (33.3%) patients in the younger old and in 26 (33.8%) in the oldest old (P = 0.095). Twenty-one patients (26.9%) in the younger old group and 13 patients (16.9%) in the oldest old group discontinued their medication (P = 0.131). There were no differences between the two groups about changes of Mini-Mental State Examination and Instrumental Activity of Daily Living scores over time.
CONCLUSION
The use of anti-dementia agents in the oldest old dementia patients may be safe and effective as the younger old dementia patients.

Keyword

Dementia; Oldest Old; Anti-dementia Medication; Adverse Effects; Efficacy; Alzheimer Disease

MeSH Terms

Aged*
Aged, 80 and over
Alzheimer Disease
Dementia*
Follow-Up Studies
Humans
Retrospective Studies