Ann Pediatr Endocrinol Metab.  2018 Mar;23(1):28-32. 10.6065/apem.2018.23.1.28.

Near final height in Korean children referred for evaluation of short stature: clinical utility and analytical validity of height prediction methods

Affiliations
  • 1Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea. 64sks@khnmc.or.kr
  • 2Department of Pediatrics, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract

PURPOSE
Predicted adult height (PAH) is often crucial to decision-making about treatment with human growth hormone (GH) or gonadotropin-releasing hormone agonist in children with short stature. This study compares final adult height (FAH) with different methods used to determine PAH and assesses the clinical utility and analytical validity of height prediction for children not treated with GH.
METHODS
Clinical findings were retrospectively analyzed, and the heights of 44 children (22 males and 22 females) who visited our clinic between August 2006 and June 2017 and reached near final adult height (NFAH) were evaluated. Children treated with GH were excluded. We compared measured NFAH to PAH using the Bayley-Pinneau (BP), Tanner-Whitehouse Mark 2, and Roche-Wainer-Thissen (RWT) methods.
RESULTS
Pearson correlation between all 3 prediction methods and NFAH showed high positive correlations in males and females (P < 0.05). The average difference between PAH and NFAH for the BP method (0.4±3.9 cm) was significantly lower than those for the RWT and TW 2 methods in females (P=0.000, analysis of variance). Furthermore, only PAH by the BP method in females was very close to measured NFAH (paired t-test). A Bland-Altman plot verified that 95% of the differences between the PAH and NFAH exist between limits of agreement (mean±1.96 standard deviation).
CONCLUSIONS
The BP method is more useful to predict NFAH in females than other methods. Careful attention is still required when using such tools because PAH can be inaccurate. Therefore, a more accurate FAH prediction model for Korean children is needed.

Keyword

Adult height prediction method; Short stature; Final height; Bayley-Pinneau method

MeSH Terms

Adult
Child*
Female
Gonadotropin-Releasing Hormone
Human Growth Hormone
Humans
Male
Methods*
Retrospective Studies
Gonadotropin-Releasing Hormone
Human Growth Hormone
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