Ann Pediatr Endocrinol Metab.  2018 Mar;23(1):28-32. 10.6065/apem.2018.23.1.28.

Near final height in Korean children referred for evaluation of short stature: clinical utility and analytical validity of height prediction methods

• Jeong SW
• Cho JH
• Jung HW
• Shim KS

• KMID: 2409787
• DOI: http://doi.org/10.6065/apem.2018.23.1.28

Abstract

PURPOSE
Predicted adult height (PAH) is often crucial to decision-making about treatment with human growth hormone (GH) or gonadotropin-releasing hormone agonist in children with short stature. This study compares final adult height (FAH) with different methods used to determine PAH and assesses the clinical utility and analytical validity of height prediction for children not treated with GH.
METHODS
Clinical findings were retrospectively analyzed, and the heights of 44 children (22 males and 22 females) who visited our clinic between August 2006 and June 2017 and reached near final adult height (NFAH) were evaluated. Children treated with GH were excluded. We compared measured NFAH to PAH using the Bayley-Pinneau (BP), Tanner-Whitehouse Mark 2, and Roche-Wainer-Thissen (RWT) methods.
RESULTS
Pearson correlation between all 3 prediction methods and NFAH showed high positive correlations in males and females (P < 0.05). The average difference between PAH and NFAH for the BP method (0.4±3.9 cm) was significantly lower than those for the RWT and TW 2 methods in females (P=0.000, analysis of variance). Furthermore, only PAH by the BP method in females was very close to measured NFAH (paired t-test). A Bland-Altman plot verified that 95% of the differences between the PAH and NFAH exist between limits of agreement (mean±1.96 standard deviation).
CONCLUSIONS
The BP method is more useful to predict NFAH in females than other methods. Careful attention is still required when using such tools because PAH can be inaccurate. Therefore, a more accurate FAH prediction model for Korean children is needed.

Keyword

Adult height prediction method; Short stature; Final height; Bayley-Pinneau method

MeSH Terms

Adult
Child*
Female
Gonadotropin-Releasing Hormone
Human Growth Hormone
Humans
Male
Methods*
Retrospective Studies
Gonadotropin-Releasing Hormone
Human Growth Hormone

Figure

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  Fig. 1. Difference between predicted by BP method and NFAH in female by Bland-Altman plot. 95% of differences between the PAH and NFAH exist between limits of agreement (mean±1.96 standard deviation [SD]; 8.0 and -7.1 cm). BP, Bayley-Pinneau; NFAH, near final adult height; PAH, predicted adult height.

Reference

References

1. Thodberg HH, Juul A, Lomholt J, Martin DD, Jenni OG, Caflisch J, et al. Adult height prediction models. In : Preedy VR, editor. Handbook of growth and growth monitoring in health and disease. New York: Springer;2012. p. 27–57.

2. BAYLEY N. Tables for predicting adult height from skeletal age and present height. J Pediatr. 1946; 28:49–64.

3. Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952; 40:423–41.

4. Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy MJ, Goldstein H, editors. Assessment of skeletal maturity and prediction of adult height (TW2 Method). 2nd ed. London: Academic Press;1975.

5. Tanner JM, Landt KW, Cameron N, Carter BS, Patel J. Prediction of adult height from height and bone age in childhood. A new system of equations (TW Mark II) based on a sample including very tall and very short children. Arch Dis Child. 1983; 58:767–76.

6. Tanner JM, Healy MJ, Goldstein H, Cameron N. Assessment of skeletal maturity and prediction of adult height (TW3 Method). 3rd ed. London: WB Saunders;2001.

7. Roche AF, Wainer H, Thissen D. The RWT method for the prediction of adult stature. Pediatrics. 1975; 56:1027–33.

8. Khamis HJ, Guo S. Improvement in the Roche-Wainer-Thissen stature prediction model: a comparative study. Am J Hum Biol. 1993; 5:669–79.

9. Thodberg HH, Jenni OG, Caflisch J, Ranke MB, Martin DD. Prediction of adult height based on automated determination of bone age. J Clin Endocrinol Metab. 2009; 94:4868–74.

10. Sperlich M, Butenandt O, Schwarz HP. Final height and predicted height in boys with untreated constitutional growth delay. Eur J Pediatr. 1995; 154:627–32.

11. Maes M, Vandeweghe M, Du Caju M, Ernould C, Bourguignon JP, Massa G. A valuable improvement of adult height prediction methods in short normal children. Horm Res. 1997; 48:184–90.

12. Kim SY, Yang SW. Assessment of bone age: a comparison of the Greulich Pyle method to the Tanner Whitehouse method. J Korean Soc Endocrinol. 1998; 13:198–204.

13. Kim SY, Oh YJ, Shin JY, Rhie YJ, Lee KH. Comparison of the Greulich-Pyle and Tanner Whitehouse (TW3) methods in bone age assessment. J Korean Soc Pediatr Endocrinol. 2008; 13:50–5.

14. Oh YJ, Yu BK, Shin JY, Lee KH, Park SH, Lee KC, et al. Comparison of predicted adult heights measured by Bayley-Pinneau and Tanner-Whitehouse 3 methods in normal hildren, those with precocious puberty and with constitutional growth delay. Korean J Pediatr. 2009; 52:351–5.

15. Korea Centers for Disease Control and Prevention; Division of Chronic Disease Surveillance; Committee for the Development of Growth Standard for Korean Children and Adolescents; Korean Pediatric Society; Committee for School Health and Public Health Statistics. 2007 Korean children and adolescents growth standard (commentary for the development of 2007 growth chart). Cheongju: Korea Centers for Disease Control and Prevention, Division of Chronic Disease Surveillance;2007.

16. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986; 1:307–10.

17. Giavarina D. Understanding Bland Altman analysis. Biochem Med (Zagreb). 2015; 25:141–51.

18. Roemmich JN, Blizzard RM, Peddada SD, Malina RM, Roche AF, Tanner JM, et al. Longitudinal assessment of hormonal and physical alterations during normal puberty in boys. IV: predictions of adult height by the Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner-Whitehouse methods compared. Am J Hum Biol. 1997; 9:371–80.

19. Brämswig JH, Fasse M, Holthoff ML, von Lengerke HJ, von Petrykowski W, Schellong G. Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: accuracy of five different methods of height prediction. J Pediatr. 1990; 117:886–91.

20. Ostojic SM. Prediction of adult height by Tanner-Whitehouse method in young Caucasian male athletes. QJM. 2013; 106:341–5.

21. Straetemans S, De Schepper J, Thomas M, Verlinde F, Rooman R; BESPEED. Validation of prediction models for near adult height in children with idiopathic growth hormone deficiency treated with growth hormone: a belgian registry study. Horm Res Paediatr. 2016; 86:161–8.

22. Zachmann M, Sobradillo B, Frank M, Frisch H, Prader A. Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions in normal children and in patients with various pathologic conditions. J Pediatr. 1978; 93:749–55.

23. Bueno Lozano G, Ruibal Francisco JL, Reverte Blanc F, Casado de Frías E. Accuracy of three methods of height prediction in a group of variant short stature children. An Esp Pediatr. 1998; 49:27–32.