J Liver Cancer.  2018 Mar;18(1):75-79. 10.17998/jlc.18.1.75.

A Case of Complete Response with Biliary Stenosis after Hepatic Arterial Injection and Stereotactic Body Radiotherapy to Hepatoecllular Carcinoma with Portal Vein Thrombosis

• Rim CH
• Im HJ
• Jung YG
• Chung HH
• Seo SJ
• Yoon WS

• KMID: 2409652
• DOI: http://doi.org/10.17998/jlc.18.1.75

Abstract

Curative treatment of hepatocellular carcinoma (HCC) with portal vein invasion is difficult to achieve, and the prognosis is dismal. Combining external beam radiotherapy (EBRT) with hepatic arterial infusion chemotherapy (HAIC) has shown favorable local therapeutic effects for patients with HCC exhibiting portal vein invasion. Stereotactic body radiotherapy (SBRT) is a recently developed EBRT modality that shows excellent tumor control. The combination of SBRT and HAIC for HCC with portal vein invasion has not been well-studied. We report a patient with HCC and portal vein invasion who achieved 15 months of survival with complete response status after combination SBRT and HAIC. The patient later experienced grade 3 biliary stricture and died of liver abscesses of unknown etiologies that subsequently appeared.

Keyword

Hepatocellular carcinoma; Stereotactic body radiotherapy; Hepatic arterial infusion chemotherapy; Portal vein

MeSH Terms

Carcinoma, Hepatocellular
Constriction, Pathologic*
Drug Therapy
Humans
Liver Abscess
Portal Vein*
Prognosis
Radiosurgery*
Radiotherapy
Therapeutic Uses
Venous Thrombosis*
Therapeutic Uses