J Korean Soc Radiol.  2018 Feb;78(2):88-94. 10.3348/jksr.2018.78.2.88.

Factors Affecting Coronary Arterial Calcification in Patients with Chronic Kidney Disease Who Did Not Undergo Treatment with Dialysis

• Kim K
• Kim G
• Kim Y
• Ki SY
• Bae EH
• Kim SW
• Kim YH

• KMID: 2408257
• DOI: http://doi.org/10.3348/jksr.2018.78.2.88

Abstract

PURPOSE
To investigate risk factors of coronary arterial calcification in chronic kidney disease (CKD) patients who did not undergo hemodialysis or peritoneal dialysis.
MATERIALS AND METHODS
We enrolled 83 patients of normal renal function (Group I) and 112 patients of CKD [Group II (CKD stage 1-2) and Group III (CKD stage 3-5)], who were assessed coronary artery calcium score (CACS) with cardiac CT. CACS between the groups were compared. Risk factors for coronary artery calcification in patients with CKD including diabetes, hypertension, and smoking were identified as relevant to CACS using logistic regression analysis. Serologic data of electrolytes were analyzed to evaluate effect for coronary calcification in patients with CKD.
RESULTS
Group III showed significant increment of CACS compared to Group I at the CACS level over 400 [odds ratio (OR) = 7.581, p = 0.01]. The OR were decreased in non-diabetic patients group, increased in non-hypertensive patients group, no significant differences in non-current smoker group. Serum phosphorous level was the only factor which showed significant effect for increased CACS (OR of 2.649, p = 0.02).
CONCLUSION
In CKD patients, higher stage of CKD was associated with increased CACS. Diabetes mellitus and increased serum phosphorous level would be considered as factors influencing coronary arterial calcification in CKD patients.

MeSH Terms

Calcium
Coronary Artery Disease
Coronary Vessels
Diabetes Mellitus
Dialysis*
Electrolytes
Humans
Hypertension
Kidney Failure, Chronic
Logistic Models
Peritoneal Dialysis
Renal Dialysis
Renal Insufficiency, Chronic*
Risk Factors
Smoke
Smoking
Tomography, X-Ray Computed
Calcium
Electrolytes
Smoke

Figure

• 

  Fig. 1. Measurement of Agatston coronary calcium score. Coronary arterial calcifications with attenuation above 130 Hounsfield unit is selected automatically on electrocardiography gated axial CT images (A-C), and Agatston coronary calcium score is calculated (D). Simultaneously patient's calcium score is rated on age-calcium score graphs (E).

Reference

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