J Clin Neurol.  2018 Apr;14(2):259-260. 10.3988/jcn.2018.14.2.259.

Is Corticospinal Tract Degeneration Caused by Sjögren Syndrome?

Affiliations
  • 1Department of Neurology, Chonnam National University Medical School, Gwangju, Korea. nts0022@hanmail.net
  • 2Department of Neurology, Chonnam National University Hospital, Gwangju, Korea.
  • 3Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. mlevy@jhmi.edu
  • 4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Pyramidal Tracts*

Figure

  • Fig. 1 Cervical MRI scans of the patient. A: At 2 months after symptom onset, a T2-weighted sagittal image shows no significant abnormality, but T2-weighted axial images show suspicious focal hyperintensities (arrows) in lateral motor tracts bilaterally in the cervical spinal cord. B: MRI images obtained 8 months after the onset show spinal cord atrophy primarily of the lateral motor tracts, with preservation of the posterior columns. C: At 20 months after the onset, a T2-weighted sagittal image shows a linear hyperintensity (asterisk) extending to the upper thoracic levels of the vertebral column (from C2 to T1), and T2-weighted axial images show more-prominent atrophy in both the lateral and ventral columns (arrow heads), which correspond to the area of lateral and anterior corticospinal tracts.


Reference

1. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, et al. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 2012; 64:475–487.
Article
2. Massara A, Bonazza S, Castellino G, Caniatti L, Trotta F, Borrelli M, et al. Central nervous system involvement in Sjögren's syndrome: unusual, but not unremarkable--clinical, serological characteristics and outcomes in a large cohort of Italian patients. Rheumatology. 2010; 49:1540–1549.
Article
3. Lin CC, Chiu MJ. Teaching neuroimage: cervical cord atrophy with dorsal root ganglionopathy in Sjögren syndrome. Neurology. 2008; 70:e27.
4. McGavern DB, Murray PD, Rivera-Quiñones C, Schmelzer JD, Low PA, Rodriguez M. Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis. Brain. 2000; 123:519–531.
Article
5. Kim MJ, Lee MC, Lee JH, Chung SJ. Cerebellar degeneration associated with Sjögren's syndrome. J Clin Neurol. 2012; 8:155–159.
Article
6. Blisard KS, Follis F, Wong R, Miller KB, Wernly JA, Scremin OU. Degeneration of axons in the corticospinal tract secondary to spinal cord ischemia in rats. Paraplegia. 1995; 33:136–140.
Article
7. Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC. Primary lateral sclerosis. clinical features, neuropathology and diagnostic criteria. Brain. 1992; 115:495–520.
Article
8. Floeter MK, Mills R. Progression in primary lateral sclerosis: a prospective analysis. Amyotroph Lateral Scler. 2009; 10:339–346.
Article
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