J Dent Anesth Pain Med.  2018 Feb;18(1):19-25. 10.17245/jdapm.2018.18.1.19.

Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study

• Goswami D
• Jain G
• Mohod M
• Baidya DK
• Bhutia O
• Roychoudhury A

• KMID: 2405379
• DOI: http://doi.org/10.17245/jdapm.2018.18.1.19

Abstract

BACKGROUND
Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling postoperative pain following third molar extraction.
METHODS
A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol. Oral ibuprofen and paracetamol was the rescue analgesic drug in group A. Patients were evaluated on the 3(rd) and 7(th) post-operative days (POD) for pain using the visual analogue score (VAS), trismus, total number of analgesics consumed, and satisfaction level of patients.
RESULTS
The VAS in groups A and B on POD3 and POD7 was 4.55 ± 2.54 and 3.95 ± 1.8, and 1.2 ± 1.64 and 0.95 ± 1.14, respectively and was statistically insignificant. The number of analgesics consumed in groups A and B on POD3 (5.25 ± 2.22 and 6.05 ± 2.43) was not statistically different from that consumed on POD7 (9.15 ± 5.93 and 10.65 ± 6.46). The p values for trismus on POD3 and POD7 were 0.609 and 0.490, respectively and those for patient satisfaction level on POD3 and POD7 were 0.283 and 0.217, respectively.
CONCLUSIONS
Benzydamine hydrochloride oral rinses do not significantly reduce intake of oral analgesics and are inadequate for pain relief following mandibular third molar extraction.

Keyword

Benzydamine Hydrochloride; Third Molar; Tooth Extraction; Topical Application

MeSH Terms

Acetaminophen
Analgesics
Benzydamine*
Humans
Ibuprofen
Molar, Third*
Pain, Postoperative
Patient Satisfaction*
Pilot Projects*
Tooth Extraction
Trismus
Acetaminophen
Analgesics
Benzydamine
Ibuprofen

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