Blood Res.  2017 Dec;52(4):329-332. 10.5045/br.2017.52.4.329.

A young man with acute respiratory distress syndrome: eosinophilia is not always “benign”

• Jain A
• Malhotra P
• Suri V
• Agarwal R
• Bal A
• Varma S

• KMID: 2405075
• DOI: http://doi.org/10.5045/br.2017.52.4.329

Abstract

No abstract available.

MeSH Terms

Eosinophilia*
Respiratory Distress Syndrome, Adult*

Figure

• 

  Fig. 1 (A) Chest X-ray (posteroanterior view) showing diffuse alveolar opacities with a normal cardiac shadow. (B) Chest X-ray 1 week after treatment with imatinib mesylate showing complete resolution of the infiltrates.

• 

  Fig. 2 (A, B) Computed tomography scans showing confluent symmetrical central airspace shadows indicating pulmonary edema.

• 

  Fig. 3 Photomicrographs showing (A) intra-alveolar Masson bodies indicating an organizing pneumonia pattern (hematoxylin and eosin, ×200), (B) Masson bodies (Masson's trichrome stain, ×200), (C) a few alveoli with fibrin balls (hematoxylin and eosin, ×200), and (D) an interstitial eosinophilic infiltrate (hematoxylin and eosin, ×400).

Reference

1. Fowler AA, Hamman RF, Good JT, et al. Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med. 1983; 98:593–597.

2. Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore). 1975; 54:1–27.

3. Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007; 2:37.

4. Gotlib J. World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. Am J Hematol. 2014; 89:325–337.

5. Gotlib J, Cools J, Malone JM 3rd, Schrier SL, Gilliland DG, Coutré SE. The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management. Blood. 2004; 103:2879–2891.

6. Dulohery MM, Patel RR, Schneider F, Ryu JH. Lung involvement in hypereosinophilic syndromes. Respir Med. 2011; 105:114–121.

7. Winn RE, Kollef MH, Meyer JI. Pulmonary involvement in the hypereosinophilic syndrome. Chest. 1994; 105:656–660.

8. Savage N, George TI, Gotlib J. Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, and FGFR1: a review. Int J Lab Hematol. 2013; 35:491–500.