Clin Hypertens.  2017 ;23(1):1. 10.1186/s40885-016-0057-6.

Effects of metabolic syndrome on aortic pulse wave velocity

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea. younhj@catholic.ac.kr

Abstract

BACKGROUND
The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS).
METHODS
A total of 59 subjects (mean age, 60 ± 12 years; male:female = 35:24) were enrolled in the study and were categorized into the positive MetS (MetS[+]: N = 32) and negative group (MetS[−]: N = 27), according to the parameters set by the National Cholesterol Education Program's Adult Treatment Panel III. Pulse wave velocity (PWV) of the aorta, arm, and leg, Framingham risk score (FRS), ankle-brachial index (ABI), and carotid intima-media thickness (IMT) for vascular aging were measured for the two groups.
RESULTS
Aortic PWV (PWVaor) was significantly higher in MetS(+) than MetS(−) group (7.0 ± 1.4 m/s vs. 8.4 ± 1.6 m/s, p < 0.01), while ABI was significantly lower in MetS(+) than MetS(−) group (1.2 ± 0.1 vs. 1.1 ± 0.2, p = 0.03), respectively. FRS was significantly higher in MetS(+) than MetS(−) group (11 ± 5 vs. 14 ± 4, p = 0.05). The both mean IMT was higher in MetS(+) than MetS(−) group (right: 0.94 ± 0.20 mm vs. 0.81 ± 0.20 mm, p = 0.03; left: 0.93 ± 0.20 mm vs. 0.79 ± 0.20 mm, p = 0.03, respectively). For predicting the probability of the presence of MetS, PWVaor was an independent tool (p = 0.04; odds ratio, 1.88; 95% confidence interval, 1.03 to 3.42) and a cut-off value of PWVaor of 7.4 m/s showed a sensitivity of 66.7% and a specificity of 47.6%.
CONCLUSIONS
We suggest that PWVaor, combined with traditional tools, can play an important role as a complementary or alternative tool for the detection of vascular stiffness in never-treated individuals with MetS.

Keyword

Aorta; Pulse wave velocity; Metabolic syndrome

MeSH Terms

Adult
Aging
Ankle Brachial Index
Aorta
Arm
Carotid Intima-Media Thickness
Cholesterol
Education
Humans
Leg
Odds Ratio
Pulse Wave Analysis*
Sensitivity and Specificity
Vascular Stiffness
Cholesterol
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