J Pathol Transl Med.  2018 Jan;52(1):64-66. 10.4132/jptm.2016.11.04.

Hyalinizing Cholecystitis and Associated Carcinoma: A Case Report

• Kang Y
• Chae YS
• Kim CH
• Lee Y
• Kim DS
• Yu YD
• Kim JY

• KMID: 2403261
• DOI: http://doi.org/10.4132/jptm.2016.11.04

Abstract

No abstract available.

MeSH Terms

Cholecystitis*
Hyalin*

Figure

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  Fig. 1. Computed tomography and gross findings of hyalinizing cholecystitis and associated carcinoma. (A) Biliary computed tomography scan reveals subtle enhancement of wall thickening at the confluence of the cystic duct and the common hepatic duct (arrow). There is mild wall thickening of the gallbladder with multiple calcified gallstones in the neck portion (arrowhead). (B) Grossly, the gallbladder wall shows diffuse fibrosis and is covered by yellowish necrotic materials, without mass-like lesions.

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  Fig. 2. Microscopic findings of hyalinizing cholecystitis and associated carcinoma. (A, B) The gallbladder wall is replaced by dense lamellated eosinophilic hyaline material. Inflammatory cells are also seen. (C) A few invasive glands are longitudinally arranged in the hyalinized gallbladder wall with a denuded epithelium. (D) Multifocal carcinoma in situ lesions are found on the surface. (E) Focal clusters of invasive glands are identified in the hyalinized wall. (F) Invasive glands have irregular borders and cytologic atypia with perineural invasion.

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  Fig. 3. Microscopic findings of the common hepatic and cystic ducts. (A, B) Invasive glands infiltrate the common hepatic and cystic ducts beneath the surface epithelium. (C) The surface epithelium is relatively spared, with no intraepithelial lesion.

Reference

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