Korean J Blood Transfus.  2017 Dec;28(3):211-224. 10.17945/kjbt.2017.28.3.211.

Strategies to Prevent Transfusion-Transmitted Infection in Blood Centers

• Shin DW
• Kim H
• Kim B
• Kim TY
• Hong YJ
• Kim TS
• Park JS
• Song EY
• Park KU
• Han KS

• KMID: 2401739
• DOI: http://doi.org/10.17945/kjbt.2017.28.3.211

Abstract

There has been continuous effort to prevent transfusion-transmitted infection (TTI). Strategies to prevent TTI can be divided into two components: first, determining donor eligibility, and second, managing bacterial contamination of blood products. To determine donor eligibility, medical history taking and screening tests for infectious diseases should be performed. To prevent bacterial contamination, blood collection process should be aseptic, tests for bacterial detection should be performed, and an application of pathogen reduction technology should also be considered. In this review, screening test items and methods, including nucleic acid amplification tests for determining donor eligibility, and precautions for blood collection, bacterial detection methods, and pathogen reduction technology for the prevention of bacterial contamination of blood products were discussed in detail.

Keyword

Transfusion-transmitted infection; Donor screening; Bacterial contamination

MeSH Terms

Communicable Diseases
Donor Selection
Humans
Mass Screening
Medical History Taking
Nucleic Acid Amplification Techniques
Tissue Donors