Asia Pac Allergy.  2011 Apr;1(1):12-15. 10.5415/apallergy.2011.1.1.12.

Immunoglobulin E in health and disease

Affiliations
  • 1Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka. manori_a@yahoo.com

Abstract

The discovery of immunoglobulin E (IgE) was a breakthrough in the field of Allergy and Immunology. Our understanding of mechanisms of allergic reactions and the role of IgE in these disorders has paralleled to the discovery of treatment modalities for patients with allergy. Apart from allergic diseases, IgE is involved in pathogenesis of other disorders. Much controversy exists about the control of total IgE (tIgE) levels and allergen-specific IgE (sIgE) profiles in allergic individuals. This review aims at giving a comprehensive overview of IgE molecule and discussing the issues related to its importance in clinical setting.

Keyword

Immunoglobulin E; Allergy

MeSH Terms

Allergy and Immunology
Humans
Hypersensitivity
Immunoglobulin E*
Immunoglobulins*
Immunoglobulin E
Immunoglobulins
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