Asia Pac Allergy.  2017 Jul;7(3):156-162. 10.5415/apallergy.2017.7.3.156.

Self-report prevalence and associated factors to drug hypersensitivity in Mexican young adults

• Bedolla-Barajas M
• Puente-Fernández C
• Flores-Merino MV
• Morales-Romero J
• Domínguez-García MV

• KMID: 2396939
• DOI: http://doi.org/10.5415/apallergy.2017.7.3.156

Abstract

BACKGROUND
Drug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system. Epidemiological data related to drug hypersensitivity reactions in our country are scarce.
OBJECTIVE
To determine the prevalence of drug hypersensitivity in a group of young adults, as well as to identify associated factors.
METHODS
A structured questionnaire was applied to young people aged 18 to 25 years. The instrument was oriented to identify reactions of drug hypersensitivity, as well as the most prevalent drugs involved. In addition, a personal and family history of atopic diseases was included. Analysis for associations between variables was been done through logistic regression.
RESULTS
The prevalence of drug hypersensitivity reactions was 12% (144 of 1,200). The antibiotics were the agents most related to hypersensitivity reactions (9.8%) followed by nonsteroidal anti-inflammatory drugs (1.6%). Factors associated with drug hypersensitivity were a personal history of asthma, odds ratio (OR) 3.15 (95% confidence interval [CI], 1.44-6.91), maternal and paternal history of drug hypersensitivity, OR 2.33 (95% CI, 1.21-4.48) and OR 3.11 (95% CI, 1.22-7.92), respectively.
CONCLUSION
The results of this research show that drug hypersensitivity in young adults is a highly prevalent event and it is associated with personal history of asthma and history of drug hypersensitivity in parents.

Keyword

Drug hypersensitivity; Prevalence; Risk factors; Young adult

MeSH Terms

Anti-Bacterial Agents
Asthma
Drug Hypersensitivity*
Humans
Hypersensitivity
Immune System
Logistic Models
Odds Ratio
Parents
Prevalence*
Risk Factors
Young Adult*
Anti-Bacterial Agents

Reference

1. Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004; 113:832–836.

2. Bavbek S, Erkekol FÖ, Celik GE, Gönüllü I, Misirligil Z. Self-reported prevalence of hypersensitivity reactions against drugs among medical students: does awareness cause any difference? Pharmacoepidemiol Drug Saf. 2011; 20:154–161.

3. John LJ, Ahmed S, Anjum F, Kebab M, Mohammed N, Darwich H, Ibraheem N, Arifulla M, Sreedharan J. Prevalence of allergies among university students: a study from Ajman, United Arab Emirates. ISRN Allergy. 2014; 2014:502052.

4. Ensina LF, Amigo MH, Koch T, Guzman E, Paoli R, Nunes IC. Drug hypersensitivity in students from São Paulo, Brazil. Clinics (Sao Paulo). 2010; 65:1009–1011.

5. Gomes E, Cardoso MF, Praça F, Gomes L, Mariño E, Demoly P. Self-reported drug allergy in a general adult Portuguese population. Clin Exp Allergy. 2004; 34:1597–1601.

6. Bavbek S, Çelik GE, Aydın Ö, Erkekol FÖ, Kurşun N, Mungan D, Mısırlıgil Z. Prevalence of hypersensitivity reactions against drugs among adult population in Turkey: a self-reported survey. J Public Health. 2012; 20:585–592.

7. Lunet N, Falcão H, Sousa M, Bay N, Barros H. Self-reported food and drug allergy in Maputo, Mozambique. Public Health. 2005; 119:587–589.

8. Doña I, Blanca-López N, Torres MJ, García-Campos J, García-Núñez I, Gómez F, Salas M, Rondón C, Canto MG, Blanca M. Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients. J Investig Allergol Clin Immunol. 2012; 22:363–371.

9. Velicković J, Palibrk I, Miljković B, Velicković D, Jovanović B, Bumbasirević V, Djukanović M, Sljukić V. Self-reported drug allergies in surgical population in Serbia. Acta Clin Croat. 2015; 54:492–499.

10. Makris MP, Sergentanis TN, Aggelides X, Tzanninis S, Polyzou E, Rigopoulos D, Psaltopoulou T. Cross sectional questionnaire-based internet study: Self-perception and clinical course of drug allergy in Greece. Allergol Int. 2017; 66:59–63.

11. Gamboa PM. The epidemiology of drug allergy-related consultations in Spanish Allergology services: Alergológica-2005. J Investig Allergol Clin Immunol. 2009; 19:Suppl 2. 45–50.

12. Thong BY, Tan TC. Epidemiology and risk factors for drug allergy. Br J Clin Pharmacol. 2011; 71:684–700.

13. Kurt E, Demir AU, Cadirci O. Immediate type drug hypersensitivity reactions and associated risk factors in an adult Turkish men population. Iran J Allergy Asthma Immunol. 2010; 9:245–250.

14. Demoly P, Bousquet J. Epidemiology of drug allergy. Curr Opin Allergy Clin Immunol. 2001; 1:305–310.

15. Puente-Fernández C, Maya-Hernández RL, Flores-Merino MV, Romero-Figueroa Mdel S, Bedolla-Barajas M, Domínguez García MV. Self-reported prevalence and risk factors associated with food hypersensitivity in Mexican young adults. Ann Allergy Asthma Immunol. 2016; 116:523–527.e3.

16. Wong J, Knott JC, Taylor DC, MacBean CE. Prevalence and validity of self-reported antibiotic allergy in Emergency Department patients. J Pharma Pract Res. 2008; 38:92–95.

17. Çelik GE, Karakaya G, Öztürk AB, Gelincik A, Abadoğlu O, Sin A, Damadoğlu E, Yılmaz İ, Demirtürk M, Dursun B, Özdemir SK, Çelikel S, Değirmenci P, Bozkurt B, Göksel Ö, Erkekol FÖ, Ayın Ö, Kavut AB, Kğrmaz C, Kalpaklğoğlu F, Büyüköztürk S, Kalyoncu F. Drug allergy in tertiary care in Turkey: results of a national survey. The ADAPT study: adult drug allergy perception in Turkey. Allergol Immunopathol (Madr). 2014; 42:573–579.

18. Jares EJ, Sánchez-Borges M, Cardona-Villa R, Ensina LF, Arias-Cruz A, Gómez M, Barayazarra S, Bernstein JA, Serrano CD, Cuello MN, Morfin-Maciel BM, De Falco A, Cherrez-Ojeda I. Latin America Drug Allergy Interest Group. Multinational experience with hypersensitivity drug reactions in Latin America. Ann Allergy Asthma Immunol. 2014; 113:282–289.

19. Diario Oficial de la Federación. Acuerdo por el que se determinan los lineamientos a los que estará sujeta la venta y dispensación de antibióticos (in Spanish) [Internet]. Ciudad de México (México): Diario Oficial de la Federación;2017. cited 2016 Dec 19. Available from: http://dof.gob.mx/nota_detalle.php?codigo=5144336&fecha=27/05/2010.

20. Rodríguez del Río P, González-Gutiérrez ML, Sánchez-López J, Nuñez-Acevedo B, Bartolomé Alvarez JM, Martínez-Cócera C. Urticaria caused by antihistamines: report of 5 cases. J Investig Allergol Clin Immunol. 2009; 19:317–320.

21. Kim MY, Jo EJ, Chang YS, Cho SH, Min KU, Kim SH. A case of levocetirizine-induced fixed drug eruption and cross-reaction with piperazine derivatives. Asia Pac Allergy. 2013; 3:281–284.

22. Chang YS, Kwon HS, Cho SH, Kim YY, Min KU. A case of urticaria induced by both hydroxyzine and cetirizine but not by levocetirizine. Allergy. 2007; 62:819–821.

23. Barranco P, López-Serrano MC, Moreno-Ancillo A. Anaphylactic reaction due to diphenhydramine. Allergy. 1998; 53:814.

24. Weidinger S, Mempel M, Ollert M, Elser I, Rakoski J, Köhn FM, Ring J. Anaphylaxis to mizolastine. J Allergy Clin Immunol. 2004; 114:979–981.

25. Schnyder B, Pichler WJ. Allergy to sulfonamides. J Allergy Clin Immunol. 2013; 131:256–257. e1–e5.

26. Varghese M, Lockey RF. Aspirin-exacerbated asthma. Allergy Asthma Clin Immunol. 2008; 4:75–83.

27. Park SM, Park JS, Park HS, Park CS. Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways. Allergy Asthma Immunol Res. 2013; 5:258–276.